Quorum sensing by farnesol revisited
Quorum sensing by farnesol revisited
复制标题
重新审视金合欢醇的群体感应
DOI：
10.1007/s00294-017-0683-x
复制
发表时间：
2017
期刊：
影响因子：
2.5
通讯作者：
Jacobsen ID
中科院分区：
文献类型：
--
作者：
Polke M;Jacobsen ID
Quorum sensing, a form of molecular communication in microbial communities, is relatively well studied in bacterial species, but poorly understood in fungi. Farnesol, a quorum sensing molecule secreted by the opportunistic human pathogenic fungusCandida albicans, was the first quorum sensing molecule described in a eukaryotic organism. However, despite considerable research efforts and advances in recent years, the mechanisms behind its action remain largely elusive. Only recently, we showed that deletion of theC. albicansgeneEED1(eed1Δ), which is essential for hyphal maintenance, resulted in both increased farnesol production and hypersensitivity to farnesol, providing a link between farnesol signaling and elongated hyphal growth. This finding raised several questions concerning farnesol signaling. In this short review we use the unique phenotype of theeed1Δ mutant to summarize current hypotheses and to speculate on possible mechanisms of quorum sensing inC. albicansand its implication in fungus–host interaction, by drawing comparisons to comparatively well-studied quorum sensing systems in bacteria.
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影响因子：
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作者：
Dixon EF;Hall RA
通讯作者：
Hall RA
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作者：
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通讯作者：
Casadevall A
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Mitchell, Aaron P.
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作者：
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通讯作者：
Jacobsen, Ilse D.