Quorum sensing in fungi--a review.
Quorum sensing in fungi--a review.
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DOI：
10.3109/13693786.2011.652201
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发表时间：
2012-05
期刊：
影响因子：
2.9
通讯作者：
Casadevall A
中科院分区：
文献类型：
--
作者：
Albuquerque P;Casadevall A
群体感应(Quorum Sensing，QS)是一种依赖于细胞密度的微生物通讯机制，可以调节细菌的毒力因子分泌、生物膜形成、能力和生物发光等行为。十年前，在发现法尼醇控制致病多形性真菌白色念珠菌的丝状化后，真菌QS系统的存在被揭示出来。在过去的十年中，法尼醇作为一种信号分子在白色念珠菌的生理过程中发挥了多种作用，并对宿主细胞和其他微生物产生了不利影响。除了法尼醇，芳香醇酪醇还被发现是一种白色念珠菌QS分子(QSM)，控制着生长、形态发生和生物膜的形成。在酿酒酵母中，还发现了另外两种芳香醇，苯乙醇和色醇，它们是调节氮饥饿条件下形态发生的QSM。此外，类似于QS的种群密度依赖行为在其他几个真菌物种中也被描述过。尽管真菌QS研究仍处于初级阶段，但它的发现改变了我们对真菌王国的看法，并最终可能导致新的抗真菌疗法的发展。
Quorum sensing (QS) is a mechanism of microbial communication dependent on cell density that can regulate several behaviors in bacteria such as secretion of virulence factors, biofilm formation, competence and bioluminescence. The existence of fungal QS systems was revealed ten years ago after the discovery that farnesol controls filamentation in the pathogenic polymorphic fungus Candida albicans. In the past decade, farnesol has been shown to play multiple roles in C. albicans physiology as a signaling molecule and inducing detrimental effects on host cells and other microbes. In addition to farnesol, the aromatic alcohol tyrosol was also found to be a C. albicans QS molecule (QSM) controlling growth, morphogenesis and biofilm formation. In Saccharomyces cerevisiae, two other aromatic alcohols, phenylethanol and tryptophol were found to be QSMs regulating morphogenesis during nitrogen starvation conditions. Additionally, population density-dependent behaviors that resemble QS have been described in several other fungal species. Although fungal QS research is still in its infancy, its discovery has changed our views about the fungal kingdom and could eventually lead to the development of new antifungal therapeutics.
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影响因子：
4.9
作者：
Dumitru, R;Hornby, JM;Nickerson, KW
通讯作者：
Nickerson, KW
DOI：
10.1073/pnas.0401416101
发表时间：
2004-04-06
影响因子：
11.1
作者：
Chen, H;Fujita, M;Fink, GR
通讯作者：
Fink, GR
DOI：
10.1007/978-1-60761-971-0_16
发表时间：
2011-01-01
期刊：
QUORUM SENSING: METHODS AND PROTOCOLS
影响因子：
--
作者：
Deveau, Aurelie;Hogan, Deborah A.
通讯作者：
Hogan, Deborah A.
影响因子：
3.6
作者：
Davis-Hanna, Amber;Piispanen, Amy E.;Hogan, Deborah A.
通讯作者：
Hogan, Deborah A.
影响因子：
3.6
作者：
Cugini, Carla;Calfee, M. Worth;Hogan, Deborah A.
通讯作者：
Hogan, Deborah A.