Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season.
Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season.
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DOI：
10.1016/j.jpeds.2023.113491
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发表时间：
2023-09
期刊：
影响因子：
--
通讯作者：
Alden NB
中科院分区：
文献类型：
--
作者：
Rao S;Armistead I;Tyler A;Lensing M;Dominguez SR;Alden NB
比较2021-2022年呼吸道病毒共循环季节期间因呼吸道合胞病毒（RSV）、流感或严重急性呼吸综合征冠状病毒2型住院的儿童的人口统计学特征、临床特征和结局。我们使用科罗拉多的医院呼吸监测数据进行了一项回顾性队列研究，比较了2021年10月1日至2022年4月30日期间入院并接受标准化分子检测的18岁以下冠状病毒病（COVID-19）、流感和RSV住院病例。多变量对数二项回归模型评估病原体类型与诊断、重症监护室入院、住院时间和接受的最高水平呼吸支持之间的相关性。在847例住院病例中，490例（57.9%）与RSV相关，306例（36.1%）与COVID-19相关，51例（6%）与流感相关。大多数RSV病例<4岁（92.9%），而流感住院治疗见于年龄较大的儿童。与COVID-19和流感病例相比，RSV病例更可能需要高于鼻插管的氧气支持（P < .0001），尽管COVID-19病例比流感和RSV病例更可能需要有创机械通气（P < .0001）。使用多变量对数二项回归分析，与COVID-19儿童相比，流感儿童入住重症监护室的风险最高（相对风险，1.97; 95%CI，1.22-3.19），而肺炎、细支气管炎、住院时间更长和需要吸氧的风险在RSV儿童中更有可能。在呼吸道病原体共循环的季节，与流感和COVID-19儿童相比，儿童最常因RSV住院，年龄较小，需要更高的氧气支持和无创通气。
To compare demographic characteristics, clinical features, and outcomes of children hospitalized with respiratory syncytial virus (RSV), influenza, or severe acute respiratory syndrome coronavirus 2 during their cocirculation 2021-2022 respiratory virus season. We conducted a retrospective cohort study using Colorado's hospital respiratory surveillance data comparing coronavirus disease 2019 (COVID-19)-, influenza-, and RSV-hospitalized cases < 18 years of age admitted and undergoing standardized molecular testing between October 1, 2021, and April 30, 2022. Multivariable log-binomial regression modeling evaluated associations between pathogen type and diagnosis, intensive care unit admission, hospital length of stay, and highest level of respiratory support received. Among 847 hospitalized cases, 490 (57.9%) were RSV associated, 306 (36.1%) were COVID-19 associated, and 51 (6%) were influenza associated. Most RSV cases were <4 years of age (92.9%), whereas influenza hospitalizations were observed in older children. RSV cases were more likely to require oxygen support higher than nasal cannula compared with COVID-19 and influenza cases (P < .0001), although COVID-19 cases were more likely to require invasive mechanical ventilation than influenza and RSV cases (P < .0001). Using multivariable log-binomial regression analyses, compared with children with COVID-19, the risk of intensive care unit admission was highest among children with influenza (relative risk, 1.97; 95% CI, 1.22-3.19), whereas the risk of pneumonia, bronchiolitis, longer hospital length of stay, and need for oxygen were more likely among children with RSV. In a season with respiratory pathogen cocirculation, children were hospitalized most commonly for RSV, were younger, and required higher oxygen support and non-invasive ventilation compared with children with influenza and COVID-19.
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DOI：
10.1056/nejmoa2203209
发表时间：
2022-08-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
13.8
作者：
Mattila, Suvi;Paalanne, Niko;Honkila, Minna;Pokka, Tytti;Tapiainen, Terhi
通讯作者：
Tapiainen, Terhi
影响因子：
120.7
作者：
Thompson, WW;Shay, DK;Fukuda, K
通讯作者：
Fukuda, K
影响因子：
5.5
作者：
Blyth, Christopher C.;Cheng, Allen C.;Macartney, Kristine K.
通讯作者：
Macartney, Kristine K.
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P