Cadence of procreation: orchestrating embryo-uterine interactions.

Cadence of procreation: orchestrating embryo-uterine interactions.
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DOI:
10.1016/j.semcdb.2014.05.005
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发表时间:
2014-10
影响因子:
7.3
通讯作者:
Dey SK
Dey SK
中科院分区:
生物学2区
文献类型:
--
作者:
Cha J;Dey SK

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真兽类哺乳动物的胚胎植入是一个高度复杂的过程,需要囊胚期胚胎的不同细胞类型和接受子宫之间的相互通讯。植入事件是动态的,在特定物种的时间内高度精心策划,许多基因具有独特且重叠的表达。不同物种的延迟植入有助于阐明植入时机和不同植入过程模式的一些复杂性。这些事件如何在时间和空间上协调尚不清楚。我们讨论关于中央和本地时钟机制的这些事件的精确计时的潜在调节器。本综述的重点是小鼠早期妊娠事件的时间安排和同步性以及妊娠后期异常的后果。
Embryo implantation in eutherian mammals is a highly complex process and requires reciprocal communication between different cell types of the embryo at the blastocyst stage and receptive uterus. The events of implantation are dynamic and highly orchestrated over a species-specific period of time with distinctive and overlapping expression of many genes. Delayed implantation in different species has helped elucidate some of the intricacies of implantation timing and different modes of the implantation process. How these events are coordinated in time and space are not clearly understood. We discuss potential regulators of the precise timing of these events with respect to central and local clock mechanisms. This review focuses on the timing and synchronization of early pregnancy events in mouse and consequences of their aberrations at later stages of pregnancy.
DOI: 10.1038/nm.3012
发表时间: 2012-12
期刊: Nature medicine
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