Latent class analysis of early developmental trajectory in baby siblings of children with autism.
Latent class analysis of early developmental trajectory in baby siblings of children with autism.
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DOI：
10.1111/j.1469-7610.2012.02558.x
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Bauman M
中科院分区：
文献类型：
--
作者：
Landa RJ;Gross AL;Stuart EA;Bauman M
自闭症儿童的兄弟姐妹（姐妹- a）患自闭症谱系障碍（ASD）和轻度损伤的遗传风险更高。为了阐明兄弟姐妹- a在不考虑诊断分类的情况下所表现出的早期发育轨迹的多样性和轮廓，使用了潜在类模型。采用Mullen早期学习量表对6-36月龄的姐妹a （n=204）进行评估。Mullen T分数作为因变量。36个月大时的结局分类包括：ASD (n=52)；非asd社交/沟通延迟（广义自闭症表型；BAP） （n=31）；未受影响（n=121）。使用潜在类别增长分析研究儿童特定表现模式。然后，通过估计分配给每个诊断分类的儿童的班级内比例，将潜在班级成员与诊断结果联系起来。4级车受到青睐。第一类代表加速发展，由25.7%的样本组成，主要是未受影响的儿童。第2类（占样本的40.0%），其特征是规范发展，非语言认知结果高于平均水平。第3类（占样本的22.3%）的特征是接受性语言，以及大和精细运动延迟。第4类（占样本的12.0%），其特征是广泛的技能习得延迟，反映在下降的轨迹上。结果诊断为ASD的儿童分布在2年级、3年级和4年级。结果支持ASD的一个类别，涉及早期非社会发展的减缓。接受性语言和运动发育在有或没有ASD结果的a姐妹中很容易受到早期延迟的影响。非asd兄弟姐妹a很大程度上分布在各个班级，表现为平均或加速发展。运动、语言和认知的发展轨迹似乎独立于非asd兄弟姐妹- a的沟通和社交延迟。
Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. Sibs-A (n=204) were assessed with the Mullen Scales of Early Learning from age 6–36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (n=52); non-ASD social/communication delay (broader autism phenotype; BAP) (n=31); and unaffected (n=121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A.
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影响因子：
0.9
作者：
HANSEN, WB;TOBLER, NS;GRAHAM, JW
通讯作者：
GRAHAM, JW
DOI：
10.1176/appi.ajp.2010.09101470
发表时间：
2010-11
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Constantino JN;Zhang Y;Frazier T;Abbacchi AM;Law P
通讯作者：
Law P
DOI：
10.1111/j.1469-7610.2006.01531.x
发表时间：
2006-06-01
影响因子：
7.6
作者：
Landa, Rebecca;Garrett-Mayer, Elizabeth
通讯作者：
Garrett-Mayer, Elizabeth
影响因子：
3.9
作者：
Gamliel, Ifat;Yirmiya, Nurit;Sigman, Marian
通讯作者：
Sigman, Marian
影响因子：
10.5
作者：
Hoekstra, R. A.;Happe, F.;Ronald, A.
通讯作者：
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