Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels.
Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels.
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DOI：
10.1038/s41598-018-23441-z
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发表时间：
2018-03-23
影响因子：
4.6
通讯作者：
Yoshimura M
中科院分区：
文献类型：
--
作者：
Sugawa S;Masuda I;Kato K;Yoshimura M
由于缺乏研究集中在极低的B型利钠肽（BNP）水平的生物学意义，我们调查了极低的BNP水平是否会对心血管系统有害，由于心脏保护受损。通过使用心肌肌钙蛋白I（cTnI）作为心血管疾病的指标，我们评估了低BNP水平人群中cTnI与BNP是否呈负相关。本研究共纳入2，001例年龄大于38岁的明显健康受试者。我们通过限制最大BNP水平（临界值范围为1 - 20 pg/mL）从该人群中定义亚组，并通过比较每个亚组中的log（BNP）与log（cTnI）进行协方差结构分析。当BNP临界值从20 pg/mL（β = 0.04）降至1 pg/mL（β =-0.29）时，log（BNP）和log（cTnI）之间的β值急剧下降，当BNP临界值低于4 pg/mL时，β值变得显著（p < 0.005）。在BNP水平低于4 pg/mL的亚组中，cTnI水平升高与BNP水平呈负相关（p < 0.005），这表明BNP不足可能在心血管异常的发生中起致病作用。
Because of the lack of studies focused on the biological implications of extremely low B-type natriuretic peptide (BNP) levels, we investigated whether extremely low BNP levels could be harmful to the cardiovascular system due to compromised cardio-protection. By using cardiac troponin I (cTnI) as an indicator of cardiovascular disorder, we assessed whether cTnI was inversely associated with BNP in populations with low BNP levels. A total of 2,001 apparently healthy subjects older than 38 years were included in this study. We defined subgroups from this population by limiting the maximum BNP level with cut-off values ranging from 1 through 20 pg/mL and performed covariance structure analyses by comparing log(BNP) with log(cTnI) in each subgroup. The beta values between log(BNP) and log(cTnI) sharply decreased as the BNP cut-off was reduced from 20 pg/mL (beta = 0.04) to 1 pg/mL (beta = −0.29) and became significant when the BNP cut-off levels were lower than 4 pg/mL (p < 0.005). In subgroups with BNP levels lower than 4 pg/mL, elevation in cTnI level was inversely associated with BNP (p < 0.005), which suggests that insufficient BNP may play a pathogenic role in the occurrence of cardiovascular abnormalities.
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DOI：
10.1253/circj.cj-15-0589
发表时间：
2015
期刊：
Circulation journal : official journal of the Japanese Circulation Society
影响因子：
--
作者：
Gupta DK;Wang TJ
通讯作者：
Wang TJ
影响因子：
5.4
作者：
Addison D;Seidelmann SB;Janjua SA;Emami H;Staziaki PV;Hallett TR;Szilveszter B;Lu MT;Cambria RP;Hoffmann U;Chan AW;Wirth LJ;Neilan TG
通讯作者：
Neilan TG
DOI：
10.1136/bmj.h910
发表时间：
2015-03-04
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Roberts E;Ludman AJ;Dworzynski K;Al-Mohammad A;Cowie MR;McMurray JJ;Mant J;NICE Guideline Development Group for Acute Heart Failure
通讯作者：
NICE Guideline Development Group for Acute Heart Failure
影响因子：
3.4
作者：
Durak-Nalbantic, Azra;Dzubur, Alen;Zvizdic, Faris
通讯作者：
Zvizdic, Faris
影响因子：
15.9
作者：
MUKOYAMA, M;NAKAO, K;IMURA, H
通讯作者：
IMURA, H