The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study system for evaluation of optical coherence tomograms: SCORE study report 4.

The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study system for evaluation of optical coherence tomograms: SCORE study report 4.
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DOI:
10.1001/archophthalmol.2009.277
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发表时间:
2009-11
影响因子:
--
通讯作者:
VanVeldhuisen, Paul C.
VanVeldhuisen, Paul C.
中科院分区:
其他
文献类型:
--
作者:
Domalpally, Amitha;Blodi, Barbara A.;Scott, Ingrid U.;Ip, Michael S.;Oden, Neal L.;Lauer, Andreas K.;VanVeldhuisen, Paul C.

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描述标准护理与皮质类固醇治疗视网膜静脉阻塞(SCORE)研究参与者的光学相干断层扫描(OCT)图像的分级程序。使用快速黄斑和十字准线扫描方案,在临床部位使用层状OCT进行光学相干断层扫描。在中央阅读中心对图像的纸质打印进行了评估。质量评估确定了OCT测量的视网膜厚度数据的准确性,并将其归类为良好、一般、边缘或不分级。在边缘图像上进行中心点厚度的手动测量。形态学检查发现囊样间隙、视网膜下积液和玻璃体-视网膜界面异常。通过正式的质量控制练习评估分级的重复性。随机选择了一组106张图像进行质量控制。前两次年度评分显示91%和对OCT质量的一致性。手动测量的中心点厚度的组内相关系数为每年0.99。对于形态变量,囊样间隙的分级符合率分别为83%和76%。视网膜下液和玻璃体视网膜界面异常的重复性不能解释,因为它们在样本中的存在有限。SCORE研究中使用的光学相干断层扫描评估程序是可重复性的,可用于视网膜静脉阻塞的多中心纵向研究。
To describe grading procedures for optical coherence tomographic (OCT) images of participants in the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study. Optical coherence tomograms were taken at clinical sites with the Stratus OCT using fast macular and crosshair scan protocols. Paper prints of images were evaluated at a central reading center. Quality evaluation identified the accuracy of OCT-measured retinal thickness data and was categorized as good, fair, borderline, or ungradable. Manual measurement of center point thickness was performed on borderline images. Morphological evaluation identified cystoid spaces, subretinal fluid, and vitreoretinal interface abnormalities. Reproducibility of grading was assessed through formal quality control exercises. A randomly selected set of 106 images was identified for quality control. The first 2 annual regrades showed 91% and 89% intergrader agreement for OCT quality. Intraclass correlation for manually measured center point thickness was 0.99 per year. For morphological variables, intergrader agreement for cystoid spaces was 83% and 76%. Reproducibility for subretinal fluid and vitreoretinal interface abnormalities could not be interpreted owing to their limited presence in the sample. Optical coherence tomogram evaluation procedures used in the SCORE Study are reproducible and can be used for multicenter longitudinal studies of retinal vein occlusion.
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