Intratumoral drug delivery with nanoparticulate carriers.
Intratumoral drug delivery with nanoparticulate carriers.
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DOI：
10.1007/s11095-010-0360-y
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发表时间：
2011-08
影响因子：
3.7
通讯作者：
Yeo, Yoon
中科院分区：
文献类型：
--
作者：
Holback, Hillary;Yeo, Yoon
关键词：
坚硬的细胞外基质、升高的间质液压力以及对实体瘤块的外周区域中的肿瘤细胞的亲和力长期以来被认为是小分子量药物和抗体扩散的显著障碍。然而，它们对基于纳米颗粒的药物递送的影响直到最近才开始受到应有的关注。本文综述了许多实体瘤的生物学特征，影响药物和纳米颗粒的运输和性质的纳米颗粒相关的肿瘤内运输，在各种肿瘤模型的研究。我们还讨论了几种实验方法，用于增强肿瘤内纳米粒子的渗透。纳米颗粒分布对化疗有效性的影响仍有待研究，在设计新的纳米颗粒药物载体时应予以考虑。
Stiff extracellular matrix, elevated interstitial fluid pressure, and the affinity for the tumor cells in the peripheral region of a solid tumor mass have long been recognized as significant barriers to diffusion of small-molecular-weight drugs and antibodies. However, their impacts on nanoparticle-based drug delivery have begun to receive due attention only recently. This article reviews biological features of many solid tumors that influence transport of drugs and nanoparticles and properties of nanoparticles relevant to their intratumoral transport, studied in various tumor models. We also discuss several experimental approaches employed to date for enhancement of intratumoral nanoparticle penetration. The impact of nanoparticle distribution on the effectiveness of chemotherapy remains to be investigated and should be considered in the design of new nanoparticulate drug carriers.
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影响因子：
17.1
作者：
Contreras J;Xie J;Chen YJ;Pei H;Zhang G;Fraser CL;Hamm-Alvarez SF
通讯作者：
Hamm-Alvarez SF
影响因子：
2.8
作者：
Boehme, Ute;Scheler, Ulrich
通讯作者：
Scheler, Ulrich
影响因子：
6.4
作者：
Albinger-Hegyi, Andrea;Stoeckli, Sandro J.;Hegyi, Ivan
通讯作者：
Hegyi, Ivan
影响因子：
--
作者：
Choi, Ki Young;Min, Kyung Hyun;Jeong, Seo Young
通讯作者：
Jeong, Seo Young
影响因子：
4.7
作者：
Bae, Y;Nishiyama, N;Kataoka, K
通讯作者：
Kataoka, K