New mechanisms for the kidney-protective effect of alkali in chronic kidney disease.
New mechanisms for the kidney-protective effect of alkali in chronic kidney disease.
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碱对慢性肾脏病的肾脏保护作用的新机制。
DOI：
10.1042/cs20220395
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Mannon,ElinorC
中科院分区：
文献类型：
--
作者：
O'Connor,PaulM;Mannon,ElinorC
Worldwide, more than one in ten adults are estimated to have chronic kidney disease (CKD). As CKD progresses, both the cost of treatment and associated risk of morbidity and mortality increase exponentially. As such, there is a great need for therapies that effectively slow CKD progression. Evidence from several small clinical trials indicates that alkali therapy may slow the rate of CKD progression. The biological mechanisms underlying this protective effect, however, remain unknown. In their recently published manuscript, Pastor Arroyo et al. (Clin Sci(Lond)(2022)136(8): https://doi.org/10.1042/CS20220095) demonstrate that the alkali sodium bicarbonate protects against loss of renal function in a crystal nephropathy model in mice. Using unbiased approaches in both mice and human tissue, the authors go on to identify two novel mechanisms that may underly this protection. The first pathway is through promoting pathways of cell metabolism, which they speculate helps the remaining functional nephrons adapt to the greater metabolic needs required to maintain kidney filtration. The second pathway is by restoration of α-Klotho levels, which may limit the expression of adhesion molecules in the injured kidney. This, the authors speculate, may prevent inflammation from driving the functional decline of the kidney. Identifying these novel pathways represents an important step forward harnessing the potential benefits of alkali therapy in CKD.
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钙通道阻滞剂对血清素摄取的影响
DOI：
10.3181/00379727-193-43043
发表时间：
1990
影响因子：
--
作者：
N. Hill;S. Lee;B. Fanburg
通讯作者：
B. Fanburg
维拉帕米对大鼠对乙醇的生理和行为反应的影响。
影响因子：
2.8
作者：
A. Rezvani;C. Mack;P. De Lacy;D. Janowsky
通讯作者：
D. Janowsky
酒精造成的认知障碍和感知风险。
DOI：
10.15288/jsa.1983.44.26
发表时间：
1983
期刊：
Journal of studies on alcohol
影响因子：
--
作者：
K. Mills;E. Bisgrove
通讯作者：
E. Bisgrove
血清素和乙醇偏好。
DOI：
--
发表时间：
1989
期刊：
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
影响因子：
--
作者：
W. Mcbride;J. Murphy;L. Lumeng;T. Li
通讯作者：
T. Li
用于量化和评估酒精消耗量的分析工具。
DOI：
--
发表时间：
1978
期刊：
Journal of Studies on Alcohol
影响因子：
--
作者：
K. Khavari;P. D. Farber
通讯作者：
P. D. Farber