Antibiotic resistance in diabetic foot infection: how it changed with COVID-19 pandemic in a tertiary care center.
Antibiotic resistance in diabetic foot infection: how it changed with COVID-19 pandemic in a tertiary care center.
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DOI：
10.1016/j.diabres.2021.108797
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发表时间：
2021-05
影响因子：
5.1
通讯作者：
Esposito K
中科院分区：
文献类型：
--
作者：
Caruso P;Maiorino MI;Macera M;Signoriello G;Castellano L;Scappaticcio L;Longo M;Gicchino M;Campitiello F;Bellastella G;Coppola N;Esposito K
调查COVID-19大流行期间糖尿病足感染（DFI）患者人群的抗生素耐药率及其主要风险因素，并与2019年人群进行比较。2019年1月至2020年12月，225名DFI患者在三级护理中心住院。通过软组织或骨组织活检的微生物检查来评估抗生素耐药性。与2019年组（n = 105）相比，2020年组（n = 120）的抗生素耐药性患病率显著更高[2019年vs 2020年，36% vs 63%，P <0.001]，并且更经常在近期或当前抗生素治疗中住院（18%vs52%，P <0.001），经常自我给药（5%vs30%，P = 0.032）。2020年组的抗生素耐药风险也较高[OR 95%CI，2.90（1.68 - 4.99）]。既往住院、抗生素自我给药和全科医生抗生素处方是抗生素耐药性的独立预测因素。于2019冠状病毒病大流行期间入住三级护理中心的DFI患者人群中，抗生素耐药性的患病率高于2019年。既往住院、抗生素自我给药/全科医生处方与抗生素耐药感染的风险较高相关。
To investigate the rate of antibiotic resistance and its main risk factors in a population of patients with diabetic foot infection (DFI) during the COVID-19 pandemic, in comparison with the population of 2019. Two hundred and twenty-five patients with DFI were admitted in a tertiary care center from January 2019 to December 2020. Antibiotic resistance was evaluated by microbiological examination of soft tissues’ or bone’s biopsy. Compared with 2019 group (n = 105), 2020 group (n = 120) had a significantly higher prevalence of antibiotic resistance [2019 vs 2020, 36% vs 63%, P <0.001] and more often was admitted with recent or current antibiotic therapy (18% vs 52%, P <0.001), which was frequently self-administered (5% vs 30%, P = 0.032). The risk of antibiotic resistance was also higher in 2020 group [OR 95% CI, 2.90 (1.68 to 4.99)]. Prior hospitalization, antibiotic self-administration and antibiotic prescription by general practitioners resulted as independent predictors of antibiotic resistance. In a population of people with DFI admitted in a tertiary care center during the COVID-19 pandemic the prevalence of antibiotic resistance was higher than 2019. Previous hospitalization, antibiotic self-administration /prescription by general practitioners were related to higher risk of antibiotic resistant infections.
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影响因子：
5.2
作者：
Lin J;Nishino K;Roberts MC;Tolmasky M;Aminov RI;Zhang L
通讯作者：
Zhang L
影响因子：
3
作者：
Abdulrazak, A;Bitar, ZI;Mobasher, LA
通讯作者：
Mobasher, LA
影响因子：
4.3
作者：
Driver, Vickie R.;Fabbi, Matteo;Gibbons, Gary
通讯作者：
Gibbons, Gary
影响因子：
8
作者：
Lipsky, Benjamin A.;Senneville, Eric;Peters, Edgar J. G.
通讯作者：
Peters, Edgar J. G.
影响因子：
11.8
作者：
de Sande-Bruinsma, Nienke Van;Grundmann, Hajo;Verloo, Didier;Tiemersma, Edine;Monen, Jos;Goossens, Herman;Ferech, Matus
通讯作者：
Ferech, Matus