Efficacy of different doses of dye-assisted internal limiting membrane peeling in idiopathic macular hole: a systematic review and network meta-analysis
Efficacy of different doses of dye-assisted internal limiting membrane peeling in idiopathic macular hole: a systematic review and network meta-analysis
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不同剂量染料辅助内界膜剥脱术治疗特发性黄斑裂孔的疗效：系统评价和网络荟萃分析
DOI：
10.1007/s10792-020-01656-2
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发表时间：
2021-01
影响因子：
1.6
通讯作者：
Xi Chen
中科院分区：
文献类型：
--
作者：
Shan-Shan Li;Min Li;Ran You;Hui-Hui Wang;Lu Zhao;Yan-Ling Wang;Xi Chen
目的玻璃体平面切除术是治疗特发性黄斑裂孔的金标准。为了提高内限制膜（ILM）的可视性，已经使用了几种染色剂，包括吲哚菁绿、台盼蓝（TB）、亮蓝G （BBG）和曲安奈德（TA）。我们进行了一项网络荟萃分析（NMA），以确定用于IMH的染色玻璃切除术染料辅助ILM剥离的最佳浓度。方法检索PubMed、Embase和Cochrane Library，检索2020年1月前的相关研究。我们使用STATA 15.1版本进行随机效应NMA，以95%置信区间评估平均差异和优势比。结果我们纳入了12项回顾性研究和5项随机对照试验（rct），包括1492例II-IV期IMH患者的ILM剥落。IMH闭合率的结果表明，不加染料的ILM剥离效果优于0.25% ICG， 0.5% ICG或TA的ILM剥离效果优于不加染料，0.05% BBG、0.15% TB、0.5% ICG或0.05% ICG的ILM剥离效果优于0.25% ICG。排序概率分析结果显示，0.15% TB或0.05% BBG对脱皮后IMH的闭合率优于其他9种染色剂。结论0.15% TB和0.05% BBG可作为治疗辅助ILM剥离治疗IMH的较好方法。对于喜欢使用ICG辅助ILM剥离的视网膜专家来说，0.05%的ICG可能是一个不错的选择。然而，建议采用高质量的大规模随机对照试验来证实NMA结果。
PurposePars plana vitrectomy is the gold standard for the treatment of idiopathic macular hole. Several chromovitrectomy dyes have been used to improve the visualization of the internal limiting membrane (ILM), including indocyanine green, trypan blue (TB), brilliant blue G (BBG), and triamcinolone acetonide (TA). We conducted a network meta-analysis (NMA) to establish the optimum concentration of chromovitrectomy dye-assisted ILM peeling for IMH.MethodsWe searched PubMed, Embase, and Cochrane Library for relevant studies before January 2020. We performed a random-effects NMA using STATA version 15.1 to assess mean difference and odds ratios with 95% confidence intervals.ResultsWe identified twelve retrospective trails and five randomized controlled trials (RCTs), comprising 1 492 patients of IMH on stage II–IV for ILM peeling. The results of IMH closure rate show that the effect of ILM peeling without dye was better than 0.25% ICG, the effects of ILM peeling with 0.5% ICG or TA were better than without dye, and the effects of ILM peeling with 0.05% BBG, 0.15% TB, 0.5% ICG or 0.05% ICG were better than 0.25% ICG. Ranking probability analysis shows that the rates of IMH closure after ILM peeling with 0.15% TB or 0.05% BBG were better than nine other concentrations of chromovitrectomy dyes.ConclusionThe 0.15% TB and 0.05% BBG were recommended as the better efficient treatment-assisted ILM peeling for IMH closure. For retina specialists who prefer to use ICG to assist ILM peeling, 0.05% ICG may be a good choice. However, high-quality large-scale RCTs are recommended to confirm the NMA results.
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影响因子：
3.4
作者：
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通讯作者：
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DOI：
10.26355/eurrev_201805_15046
发表时间：
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影响因子：
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10.1007/s00417-014-2594-6
发表时间：
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影响因子：
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通讯作者：
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影响因子：
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