Individualized localization and cortical surface-based registration of intracranial electrodes.
Individualized localization and cortical surface-based registration of intracranial electrodes.
复制标题
DOI：
10.1016/j.neuroimage.2011.11.046
复制
发表时间：
2012-02-15
期刊：
影响因子：
5.7
通讯作者：
Cash, Sydney S.
中科院分区：
文献类型：
--
作者：
Dykstra, Andrew R.;Chan, Alexander M.;Quinn, Brian T.;Zepeda, Rodrigo;Keller, Corey J.;Cormier, Justine;Madsen, Joseph R.;Eskandar, Emad N.;Cash, Sydney S.
除了广泛的临床应用外，颅内脑电图 (iEEG) 越来越多地被用作绘制正常认知功能的神经相关性以及开发神经修复术的工具。尽管最近取得了进展，但与其他已建立的脑图模式（例如功能性 MRI、脑磁图和脑电图）不同，在个体神经解剖学方面配准 iEEG 以及跨受试者的功能结果配准仍然是一个重大挑战。在这里，我们描述了一种将高分辨率术前 MRI 与术后计算机断层扫描 (CT) 联合配准的方法，目的是对正常和病理性（例如发作间期放电和癫痫发作）大脑活动进行个体化功能映射。我们的方法根据个人的神经解剖结构准确地（平均在 3 毫米以内）定位电极。此外，我们概述了体积或基于表面的组分析的原则程序。我们在五名难治性癫痫患者中展示了我们的方法，这些患者在手术切除癫痫病灶之前对癫痫病灶进行侵入性监测。该程序可直接应用于所有类型的颅内电极，对颅骨和大脑变形的鲁棒性以及比较各组患者电极位置的能力使该程序成为基础科学家和临床医生的重要工具。
In addition to its widespread clinical use, the intracranial electroencephalogram (iEEG) is increasingly being employed as a tool to map the neural correlates of normal cognitive function as well as for developing neuroprosthetics. Despite recent advances, and unlike other established brain mapping modalities (e.g. functional MRI, magneto- and electroencephalography), registering the iEEG with respect to neuroanatomy in individuals – and coregistering functional results across subjects – remains a significant challenge. Here we describe a method which coregisters high-resolution preoperative MRI with postoperative computerized tomography (CT) for the purpose of individualized functional mapping of both normal and pathological (e.g., interictal discharges and seizures) brain activity. Our method accurately (within 3mm, on average) localizes electrodes with respect to an individual’s neuroanatomy. Furthermore, we outline a principled procedure for either volumetric or surface-based group analyses. We demonstrate our method in five patients with medically-intractable epilepsy undergoing invasive monitoring of the seizure focus prior to its surgical removal. The straight-forward application of this procedure to all types of intracranial electrodes, robustness to deformations in both skull and brain, and the ability to compare electrode locations across groups of patients makes this procedure an important tool for basic scientists as well as clinicians.
登录
查看更多内容
影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.3109/10929080109146090
发表时间：
2001-01-01
期刊：
Computer aided surgery : official journal of the International Society for Computer Aided Surgery
影响因子：
--
作者：
Noordmans, H J;van Rijen, P C;Hoekema, R
通讯作者：
Hoekema, R
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
DOI：
10.1073/pnas.0807010105
发表时间：
2008-10-14
影响因子：
11.1
作者：
He, Biyu J.;Snyder, Abraham Z.;Raichle, Marcus E.
通讯作者：
Raichle, Marcus E.