Utility of recent studies to assess the National Research Council 2001 estimates of cancer risk from ingested arsenic.
Utility of recent studies to assess the National Research Council 2001 estimates of cancer risk from ingested arsenic.
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DOI：
10.1289/ehp.1002427
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发表时间：
2011-03
影响因子：
10.4
通讯作者：
Sams R
中科院分区：
文献类型：
--
作者：
Gibb H;Haver C;Gaylor D;Ramasamy S;Lee JS;Lobdell D;Wade T;Chen C;White P;Sams R
本综述的目的是评估最近流行病学文献对国家研究理事会（NRC）评估低浓度砷污染水（< 100 μg/L）对肺癌和膀胱癌风险的影响。在PubMed中检索与低剂量砷暴露导致肺癌和膀胱癌风险评估相关的流行病学研究。包括从2001年NRC评估之日到2010年9月发表的文章。14项关于肺癌和膀胱癌风险的流行病学研究被认为对分析有潜在的帮助。最近的流行病学研究，调查了肺癌和膀胱癌的风险，从低砷暴露的能力有限，以检测NRC估计的过度风险，因为样本量和小于终身暴露。虽然NRC估算所依据的台湾研究的生态性质存在一定的局限性，但这些研究的数据具有特殊的优势，因为它们描述了大量人群终身暴露导致的肺癌和膀胱癌风险，并且仍然是进行定量风险评估的最佳数据。然而，对台湾东北部人群的持续随访为改善饮用水中砷的癌症风险评估提供了最好的机会。未来对饮用水中砷< 100 μg/L以及肺癌和膀胱癌的研究应考虑样本量的充分性、砷和吸烟的协同关系、砷暴露持续时间、暴露开始和结束的年龄以及组织学亚型。
The purpose of this review is to evaluate the impact of recent epidemiologic literature on the National Research Council (NRC) assessment of the lung and bladder cancer risks from ingesting low concentrations (< 100 μg/L) of arsenic-contaminated water. PubMed was searched for epidemiologic studies pertinent to the lung and bladder cancer risk estimates from low-dose arsenic exposure. Articles published from 2001, the date of the NRC assessment, through September 2010 were included. Fourteen epidemiologic studies on lung and bladder cancer risk were identified as potentially useful for the analysis. Recent epidemiologic studies that have investigated the risk of lung and bladder cancer from low arsenic exposure are limited in their ability to detect the NRC estimates of excess risk because of sample size and less than lifetime exposure. Although the ecologic nature of the Taiwanese studies on which the NRC estimates are based present certain limitations, the data from these studies have particular strengths in that they describe lung and bladder cancer risks resulting from lifetime exposure in a large population and remain the best data on which to conduct quantitative risk assessment. Continued follow-up of a population in northeastern Taiwan, however, offers the best opportunity to improve the cancer risk assessment for arsenic in drinking water. Future studies of arsenic < 100 μg/L in drinking water and lung and bladder cancer should consider adequacy of the sample size, the synergistic relationship of arsenic and smoking, duration of arsenic exposure, age when exposure began and ended, and histologic subtype.
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影响因子：
8.3
作者：
Adair, Blakely M.;Hudgens, Edward E.;Thomas, David J.
通讯作者：
Thomas, David J.
影响因子：
5
作者：
Karagas, MR;Tosteson, TD;Morris, JS
通讯作者：
Morris, JS
DOI：
10.1038/sj.jea.7500449
发表时间：
2006-03-01
影响因子：
4.5
作者：
Ahsan, H;Chen, Y;Graziano, J
通讯作者：
Graziano, J
影响因子：
5
作者：
Bates, MN;Rey, OA;Smith, AH
通讯作者：
Smith, AH
影响因子：
3.8
作者：
Chen, Chi-Ling;Chiou, Hung-Yi;Chen, Chien-Jen
通讯作者：
Chen, Chien-Jen