Evasion of phagotrophic predation by protist hosts and innate immunity of metazoan hosts by Legionella pneumophila.
Evasion of phagotrophic predation by protist hosts and innate immunity of metazoan hosts by Legionella pneumophila.
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DOI：
10.1111/cmi.12971
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发表时间：
2019-01
影响因子：
3.4
通讯作者：
Abu Kwaik Y
中科院分区：
文献类型：
--
作者：
Best AM;Abu Kwaik Y
嗜肺军团菌是一种普遍存在的环境细菌，其已经进化为在变形虫和其他原生生物中感染和增殖。人们认为，人类意外吸入污染的水颗粒是使这种病原体在肺泡巨噬细胞内增殖并引起肺炎的原因。然而，高度进化的巨噬细胞配备了比原生生物更复杂的先天防御机制，例如吞噬营养进食进化为具有更进化的先天防御过程的吞噬作用。毫不奇怪，大多数参与吞噬体生物发生的蛋白质（约80%）起源于进化的吞噬阶段。有大量的高度进化的细胞和先天后生动物过程，在原生生物学中没有代表，这是由L。嗜肺细胞的炎症反应;包括TLR 2信号传导、NF-κB、凋亡和炎症过程、组蛋白修饰、半胱天冬酶和NLRC-Naip 5炎性体。重要的是，L。pneumophila感染无脊椎动物Galleria mellonella的血细胞，杀死G.在果蝇成虫和秀丽隐杆线虫中增殖并杀死它们。虽然与原生生物宿主的共同进化为L. pneumophila感染巨噬细胞，我们讨论了进一步的进化方面的共同进化的L。嗜肺菌及其适应性调节各种高度进化的先天后生动物过程，然后成为人类病原体。
Legionella pneumophila is a ubiquitous environmental bacterium that has evolved to infect and proliferate within amoebae and other protists. It is thought that accidental inhalation of contaminated water particles by humans is what has enabled this pathogen to proliferate within alveolar macrophages and cause pneumonia. However, the highly evolved macrophages are equipped more sophisticated innate defense mechanisms than protists, such as the evolution of phagotrophic feeding into phagocytosis with more evolved innate defense processes. Not surprisingly, the majority of proteins involved in phagosome biogenesis (~80%) have origins in the phagotrophy stage of evolution. There are a plethora of highly evolved cellular and innate metazoan processes, not represented in Protist biology, that are modulated by L. pneumophila; including TLR2 signaling, NF-κB, apoptotic and inflammatory processes, histone modification, caspases, and the NLRC-Naip5 inflammasomes. Importantly, L. pneumophila infects hemocytes of the invertebrate Galleria mellonella, kill G. mellonella larvae, and proliferate in and kill Drosophila adult flies and Caenorhabditis elegans. Although co-evolution with protist hosts has provided a substantial blueprint for L. pneumophila to infect macrophages, we discuss the further evolutionary aspects of co-evolution of L. pneumophila and its adaptation to modulate various highly evolved innate metazoan processes prior to becoming a human pathogen.
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影响因子：
12.4
作者：
Bell RAV;Megeney LA
通讯作者：
Megeney LA
影响因子：
5.7
作者：
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通讯作者：
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8
作者：
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通讯作者：
Devreotes, Peter N.
影响因子：
3.1
作者：
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通讯作者：
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影响因子：
3.4
作者：
Amer, AO;Swanson, MS
通讯作者：
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