Factors Mediating Environmental Biofilm Formation by Legionella pneumophila.
Factors Mediating Environmental Biofilm Formation by Legionella pneumophila.
复制标题
DOI：
10.3389/fcimb.2018.00038
复制
发表时间：
2018
影响因子：
5.7
通讯作者：
Amer AO
中科院分区：
文献类型：
--
作者：
Abu Khweek A;Amer AO
嗜肺军团菌（L.嗜肺军团菌（pneumophila）是一种机会性水媒病原体，也是退伍军人病的病原体，退伍军人病通过吸入受污染的水滴传播给人类。该细菌能够定殖于各种人造水系统，如冷却塔，温泉和牙科线，并广泛分布于多个生态位，包括几种原生动物。嗜肺菌能够在覆盖水系统内表面的多物种生物膜内存活和持续存在。生物膜形成L.嗜肺菌对病原体是有利的，因为它导致该细菌的持久性、传播、对治疗的抗性和毒力的增加。此外，军团菌病的暴发与军团菌的存在有关。即使在广泛的化学和物理处理之后，生物膜中的嗜肺菌也是如此。在含菌群的L.在其它生物体中，有几个因素正或负调节L.在这个细菌群落中。生物膜形成菌嗜肺菌对公众健康极为重要，并对医疗和工业界有影响。事实上，L.嗜肺菌以及感染这种细菌的患者的诊断和住院治疗花费了政府数十亿美元。因此，了解生物和环境因素，有助于持久性和生理适应的生物膜可能是有害的，以消除和防止L。嗜肺菌本文就影响L.生物膜聚生体内的嗜肺菌的优势，细菌从生物膜中存活获得的优势，生物膜形成期间的基因和基因调控，以及最后与生物膜对杀生物剂和抗军团菌治疗的抗性相关的挑战。
Legionella pneumophila (L. pneumophila) is an opportunistic waterborne pathogen and the causative agent for Legionnaires' disease, which is transmitted to humans via inhalation of contaminated water droplets. The bacterium is able to colonize a variety of man-made water systems such as cooling towers, spas, and dental lines and is widely distributed in multiple niches, including several species of protozoa In addition to survival in planktonic phase, L. pneumophila is able to survive and persist within multi-species biofilms that cover surfaces within water systems. Biofilm formation by L. pneumophila is advantageous for the pathogen as it leads to persistence, spread, resistance to treatments and an increase in virulence of this bacterium. Furthermore, Legionellosis outbreaks have been associated with the presence of L. pneumophila in biofilms, even after the extensive chemical and physical treatments. In the microbial consortium-containing L. pneumophila among other organisms, several factors either positively or negatively regulate the presence and persistence of L. pneumophila in this bacterial community. Biofilm-forming L. pneumophila is of a major importance to public health and have impact on the medical and industrial sectors. Indeed, prevention and removal protocols of L. pneumophila as well as diagnosis and hospitalization of patients infected with this bacteria cost governments billions of dollars. Therefore, understanding the biological and environmental factors that contribute to persistence and physiological adaptation in biofilms can be detrimental to eradicate and prevent the transmission of L. pneumophila. In this review, we focus on various factors that contribute to persistence of L. pneumophila within the biofilm consortium, the advantages that the bacteria gain from surviving in biofilms, genes and gene regulation during biofilm formation and finally challenges related to biofilm resistance to biocides and anti-Legionella treatments.
登录
查看更多内容
影响因子：
3.6
作者：
Bobrov AG;Kirillina O;Ryjenkov DA;Waters CM;Price PA;Fetherston JD;Mack D;Goldman WE;Gomelsky M;Perry RD
通讯作者：
Perry RD
影响因子：
3.7
作者：
Bigot, Renaud;Bertaux, Joanne;Berjeaud, Jean-Marc
通讯作者：
Berjeaud, Jean-Marc
影响因子：
3.4
作者：
Bruggemann, Holger;Hagman, Arne;Buchrieser, Carmen
通讯作者：
Buchrieser, Carmen
影响因子：
5.4
作者：
Conner JG;Zamorano-Sánchez D;Park JH;Sondermann H;Yildiz FH
通讯作者：
Yildiz FH
影响因子：
3.6
作者：
Carlson HK;Vance RE;Marletta MA
通讯作者：
Marletta MA