Unveiling the ups and downs of miR-205 in physiology and cancer: transcriptional and post-transcriptional mechanisms.
Unveiling the ups and downs of miR-205 in physiology and cancer: transcriptional and post-transcriptional mechanisms.
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DOI：
10.1038/s41419-020-03192-4
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发表时间：
2020-11-15
影响因子：
9
通讯作者：
Gandellini P
中科院分区：
文献类型：
--
作者：
Ferrari E;Gandellini P
miR-205通过调节支配分化和形态发生的多种途径在上皮细胞的生理学中起重要作用。它的异常表达经常在人类癌症中被发现，其中据报道它根据特定的肿瘤背景和靶基因而充当肿瘤抑制基因或癌基因。miR-205在不同细胞类型或过程中的表达和功能是microRNA的转录、加工和稳定性之间复杂平衡的结果。本文综述了miR-205在转录和转录后水平的主要调控机制，并重点介绍了其与宿主基因的转录关系。阐明在不同生物学背景下调节miR-205表达的机制和因子代表了更好地理解这种关键microRNA在生理学和疾病中对上皮细胞功能的贡献以及开发用于未来癌症治疗的调节策略的基本步骤。
miR-205 plays important roles in the physiology of epithelia by regulating a variety of pathways that govern differentiation and morphogenesis. Its aberrant expression is frequently found in human cancers, where it was reported to act either as tumor-suppressor or oncogene depending on the specific tumor context and target genes. miR-205 expression and function in different cell types or processes are the result of the complex balance among transcription, processing and stability of the microRNA. In this review, we summarize the principal mechanisms that regulate miR-205 expression at the transcriptional and post-transcriptional level, with particular focus on the transcriptional relationship with its host gene. Elucidating the mechanisms and factors regulating miR-205 expression in different biological contexts represents a fundamental step for a better understanding of the contribution of such pivotal microRNA to epithelial cell function in physiology and disease, and for the development of modulation strategies for future application in cancer therapy.
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影响因子：
3.7
作者：
Chang, Yan;Xue, Xinying;Chen, Liang'an
通讯作者：
Chen, Liang'an
影响因子：
2.7
作者：
Farmer, D'Juan T.;Finley, Jennifer K.;Chen, Feeling Y.;Tarifeno-Saldivia, Estefania;McNamara, Nancy A.;Knox, Sarah M.;McManus, Michael T.
通讯作者：
McManus, Michael T.
长链非编码 RNA 在癌症中的作用、功能和机制。
DOI：
10.1016/j.gpb.2015.09.006
发表时间：
2016-02
期刊：
Genomics, proteomics & bioinformatics
影响因子：
--
作者：
Fang Y;Fullwood MJ
通讯作者：
Fullwood MJ
DOI：
10.4161/cc.21476
发表时间：
2012-08-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Alla V;Kowtharapu BS;Engelmann D;Emmrich S;Schmitz U;Steder M;Pützer BM
通讯作者：
Pützer BM
影响因子：
12.4
作者：
Gandellini, P.;Profumo, V.;Zaffaroni, N.
通讯作者：
Zaffaroni, N.