Are saving appearance responses typical communication patterns in Alzheimer's disease?
Are saving appearance responses typical communication patterns in Alzheimer's disease?
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DOI：
10.1371/journal.pone.0197468
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Hashimoto M
中科院分区：
文献类型：
--
作者：
Matsushita M;Yatabe Y;Koyama A;Katsuya A;Ijichi D;Miyagawa Y;Ikezaki H;Furukawa N;Ikeda M;Hashimoto M
为了保持形象，痴呆症患者有时会假装知道正确答案，就像在进行神经心理学测试时看到的那样，如简易精神状态检查（MMSE）。痴呆症患者的这些拯救外观反应（SAR）通常会导致护理人员和/或医务人员低估痴呆症的严重程度，并妨碍适当的早期治疗。然而，大多数SAR的描述都是基于临床医生的经验知识。在这项研究中，我们调查了SAR是否是阿尔茨海默病（AD）患者的典型交流模式，与轻度认知障碍（MCI）或路易体痴呆（DLB）相比。参与者为107名AD门诊患者，16名混合AD与脑血管性痴呆，55名MCI患者和30名DLB患者。我们评估了MMSE期间SAR的发生率。采用χ2检验和Logistic回归分析比较SAR与AD的关系。AD患者SAR的发生率为57.9%，MCI患者为18.2%，DLB患者为20.0%（P < 0.05）。虽然各组诊断中某些变量存在显著差异，但logistic回归分析显示，AD患者比MCI患者更容易出现SAR（比值比= 3.48，95%机密区间= 1.18-10.28）和DLB（比值比= 4.24，95%置信区间= 1.50-12.01），即使在控制了性别、估计的疾病持续时间、MMSE和额叶评估组合评分后。在AD患者中SAR的发生率最高。临床医生应该对患有SAR的痴呆患者采取尊重的态度，因为SAR意味着患者对无法正确回答的问题的矛盾情绪。
To keep up appearances, people with dementia sometimes pretend to know the correct answer, as seen during administration of neuropsychological tests such as the Mini-Mental State Examination (MMSE). These saving appearance responses (SARs) of people with dementia often lead to caregivers and/or medical staff underestimating the severity of dementia and impede proper early initiation of treatment. However, most descriptions of SARs are based on empirical knowledge of clinicians. In this study, we investigated whether SARs are typical communication patterns in people with Alzheimer’s disease (AD), compared with mild cognitive impairment (MCI) or dementia with Lewy bodies (DLB). The participants were 107 outpatients with AD, 16 with mixed AD with cerebrovascular dementia, 55 with MCI, and 30 with DLB. We assessed the occurrence of SARs during the MMSE. The relationships between the SARs and AD were examined by the χ2 test and logistic regression analysis. People with AD who showed SARs were 57.9%, whereas those with MCI were 18.2% and DLB were 20.0% (P with Bonferroni correction < 0.05). Although there were significant differences in some variables in each group of diagnosis, logistic regression analysis showed that people with AD were more likely to show SARs than those with MCI (Odds ratio = 3.48, 95% Confidential Interval = 1.18–10.28) and DLB (Odds ratio = 4.24, 95% Confidential Interval = 1.50–12.01), even after controlling for sex, estimated disease duration, MMSE, and frontal assessment battery scores. The occurrence of SARs could be found most frequently in people with AD. Clinicians should develop a respectful attitude toward dementia patients with SARs because SARs imply conflicted feelings about questions that patients cannot answer correctly.
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DOI：
10.1186/s13195-016-0179-9
发表时间：
2016-03-16
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Heitz C;Noblet V;Phillipps C;Cretin B;Vogt N;Philippi N;Kemp J;de Petigny X;Bilger M;Demuynck C;Martin-Hunyadi C;Armspach JP;Blanc F
通讯作者：
Blanc F
影响因子：
2.6
作者：
Boiger, Michael;Gungor, Derya;Mesquita, Batja
通讯作者：
Mesquita, Batja
影响因子：
10.5
作者：
McKeith, IG
通讯作者：
McKeith, IG
DOI：
10.1177/147470491201000213
发表时间：
2012-06-29
期刊：
Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior
影响因子：
--
作者：
Sznycer D;Takemura K;Delton AW;Sato K;Robertson T;Cosmides L;Tooby J
通讯作者：
Tooby J
“转向符号”可以成为阿尔茨海默氏病的临床标志吗？
影响因子：
2.3
作者：
Fukui T;Yamazaki T;Kinno R
通讯作者：
Kinno R