Structural Diversity of Diosgenin Hydrates: Effect of Initial Concentration, Water Volume Fraction, and Solvent on Crystallization
Structural Diversity of Diosgenin Hydrates: Effect of Initial Concentration, Water Volume Fraction, and Solvent on Crystallization
复制标题
薯蓣皂苷元水合物的结构多样性：初始浓度、水体积分数和溶剂对结晶的影响
DOI：
10.1021/acs.cgd.5b01609
复制
发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Hu, Changwen
中科院分区：
文献类型：
--
作者：
Su, Chong;Lin, Zhengguo;Gu, Jingkai;Hu, Changwen
薯蓣皂苷元是一种甾体皂苷元，已合成了四种半水合物（HH-I、HH-II、HH-III和HH-IV）和两种一水合物（MH-I、MH-II）。水合物HH-I、HH-III、HH-IV、MH-I和MH-II已通过单晶X-射线衍射、粉末X-射线衍射、傅里叶变换红外光谱、热重分析和差示扫描量热法进行了彻底表征。尽管在这些情况下薯蓣皂苷元具有相似的构象，但氢键相互作用将薯蓣皂苷元和晶格水分子连接成不同的超分子结构。更重要的是，三个控制因素，包括初始浓度，水的体积分数，和溶剂，在薯蓣皂苷元水合物的结晶进行了研究。乙醇中的对照实验表明，随着初始浓度的增加，HH-III、HH-I和HH-II依次出现;随着含水量的增加，HH-I、HH-III、MH-I和MH-II依次出现。当以丙酮为溶剂时，HH-IV的溶解度最高。
Four hemihydrates (HH-I, HH-II, HH-III, and HH-IV) and two monohydrates (MH-I, MH-II) of diosgenin, a steroid sapogenin, have been prepared. Hydrates HH-I, HH-III, HH-IV, MH-I, and MH-II have been thoroughly characterized by single-crystal X-ray diffraction, powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetry, and differential scanning calorimetry. Although in these cases diosgenin has a similar conformation, hydrogen bonding interactions connect diosgenin and the lattice water molecule into different supermolecular structures. More importantly, three controlling factors, including initial concentration, water volume fraction, and solvent, have been investigated in the crystallization of diosgenin hydrates. The control experiments in ethanol display that as the initial concentration increases, HH-III, HH-I, and HH-II appear in order, and with the increase of water content, HH-I, HH-III, MH-I, and MH-II are obtained correspondingly. When acetone is used as solvent, HH-IV was...
登录
查看更多内容
DOI：
10.1107/s1600536805019884
发表时间：
2005-07
影响因子：
0.9
作者：
Xiu-feng Zhang;Yan Cui;Lan-fen Wang;Shiwei Zhang;B. Yan;Yang Liu
通讯作者：
Xiu-feng Zhang;Yan Cui;Lan-fen Wang;Shiwei Zhang;B. Yan;Yang Liu
影响因子：
7.2
作者：
Alvarez, G;Pabón, A;Blair, S
通讯作者：
Blair, S
影响因子：
15
作者：
R. Marker;J. Krueger
通讯作者：
R. Marker;J. Krueger
影响因子：
5.1
作者：
Wang, Ya-Jean;Pan, Kao-Lu;Hsu, John T. -A.
通讯作者：
Hsu, John T. -A.
影响因子：
0.8
作者：
E. Gruszecka-Kowalik;D. VanDerveer;L. Zalkow
通讯作者：
E. Gruszecka-Kowalik;D. VanDerveer;L. Zalkow