Effects of orbitofrontal cortex lesions on autoshaped lever pressing and reversal learning.
Effects of orbitofrontal cortex lesions on autoshaped lever pressing and reversal learning.
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DOI：
10.1016/j.bbr.2014.07.029
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发表时间：
2014-10-15
影响因子：
2.7
通讯作者：
Chang, Stephen E.
中科院分区：
文献类型：
--
作者：
Chang, Stephen E.
与奖励事件相关联的线索可以触发朝向线索本身的行为，这是由于线索通过其与奖励结果的配对获得激励值（即，符号跟踪）。例如，大鼠将接近、按压并试图“消耗”可伸缩杠杆条件刺激（CS），其发出食物非条件刺激（US）的递送的信号。在寻找食物时，关注食物预测CS是很重要的，当CS和US之间的关系改变时，能够改变一个人的行为也同样重要。本研究采用判别式自动成形程序和杠杆CSs，研究了眶额皮质（OFC）损伤对符号追踪和反转学习的影响。插入一个杠杆后，在缩回时输送蔗糖，插入另一个杠杆后，什么也不输送。收购阶段结束后，杠杆和结果之间的意外情况发生了逆转。双侧眶额皮层损伤对符号追踪的获得没有影响。然而，OFC损伤的大鼠表现出实质性的赤字收购迹象跟踪相比，假损伤的大鼠，一旦刺激结果的突发事件被逆转。在逆转学习的过程中，OFC损伤的大鼠能够达到与假损伤大鼠相当的符号追踪水平。这些研究结果表明，眶额皮层对于认知结构获得激励价值的能力并不是必需的，并提供了更多的证据表明，眶额皮层对于在刺激-结果意外事件发生变化后适当地改变行为至关重要
A cue associated with a rewarding event can trigger behavior towards the cue itself due to the cue acquiring incentive value through its pairing with the rewarding outcome (i.e., sign-tracking). For example, rats will approach, press, and attempt to “consume” a retractable lever conditioned stimulus (CS) that signals delivery of a food unconditioned stimulus (US). Attending to food-predictive CSs is important when seeking out food, and it is just as important to be able to modify one’s behavior when the relationships between CSs and USs are changed. Using a discriminative autoshaping procedure with lever CSs, the present study investigated the effects of orbitofrontal cortex (OFC) lesions on sign-tracking and reversal learning. Insertion of one lever was followed by sucrose delivery upon retraction, and insertion of another lever was followed by nothing. After the acquisition phase, the contingencies between the levers and outcomes were reversed. Bilateral OFC lesions had no effect on the acquisition of sign-tracking. However, OFC-lesioned rats showed substantial deficits in acquiring sign-tracking compared to sham-lesioned rats once the stimulus-outcome contingencies were reversed. Over the course of reversal learning, OFC-lesioned rats were able to reach comparable levels of sign-tracking as sham-lesioned rats. These findings suggest that OFC is not necessary for the ability of a CS to acquire incentive value and provide more evidence that OFC is critical for modifying behavior appropriately following a change in stimulus-outcome contingencies
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影响因子：
2
作者：
Schoenbaum, G;Setlow, B;Gallagher, M
通讯作者：
Gallagher, M
影响因子：
2.7
作者：
Chang, Stephen E.;Holland, Peter C.
通讯作者：
Holland, Peter C.
影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
2.7
作者：
STIERS, M;SILBERBERG, A
通讯作者：
SILBERBERG, A
影响因子：
5.3
作者：
Ostlund, Sean B.;Balleine, Bernard W.
通讯作者：
Balleine, Bernard W.