Effects of nucleus accumbens core and shell lesions on autoshaped lever-pressing.
Effects of nucleus accumbens core and shell lesions on autoshaped lever-pressing.
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DOI：
10.1016/j.bbr.2013.07.046
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发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Holland, Peter C.
中科院分区：
文献类型：
--
作者：
Chang, Stephen E.;Holland, Peter C.
某些巴甫洛夫条件刺激（CS）与食物非条件刺激（US）配对，在大鼠中引起接近甚至消费样行为（符号追踪）。我们调查的影响，病变的髓核核心（ACbC）或壳（ACbS）收购的标志跟踪在一个判别自动成形程序，其中介绍一个杠杆CS随后交付蔗糖，另一个没有。虽然我们以前发现，整个ACb的双侧病变破坏了符号跟踪的初始采集，ACbC或ACbS病变都不影响大鼠按下CS+的试验的速率或百分比。此外，详细的视频分析显示，任何病变的地形标志跟踪条件反应（CR）没有影响。这些和其他来自自动成形的损伤研究的结果与先前的使用纯粹视觉线索的符号追踪实验的结果形成了对比（Parkinson，Robbins，and Everitt，2000 a; Parkinson，Willoughby，Robbins，and Everitt，2000 b），这表明参与分配激励值的神经回路取决于CS的性质。
Certain Pavlovian conditioned stimuli (CSs) paired with food unconditioned stimuli (USs) come to elicit approach and even consumption-like behaviors in rats (sign-tracking). We investigated the effects of lesions of the nucleus accumbens core (ACbC) or shell (ACbS) on the acquisition of sign-tracking in a discriminative autoshaping procedure in which presentation of one lever CS was followed by delivery of sucrose, and another was not. Although we previously found that bilateral lesions of the whole ACb disrupted the initial acquisition of sign-tracking, neither ACbC or ACbS lesions affected the rate or percentage of trials in which rats pressed the CS+. In addition, detailed video analysis showed no effect of either lesion on the topography of the sign-tracking conditioned response (CR). These and other results from lesion studies of autoshaping contrast with those from previous sign-tracking experiments that used purely visual cues (Parkinson, Robbins, and Everitt, 2000a; Parkinson, Willoughby, Robbins, and Everitt, 2000b), suggesting that the neural circuitry involved in assigning incentive value depends upon the nature of the CS.
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影响因子：
7.6
作者：
Flagel, Shelly B.;Robinson, Terry E.;Clark, Jeremy J.;Clinton, Sarah M.;Watson, Stanley J.;Seeman, Phillip;Phillips, Paul E. M.;Akil, Huda
通讯作者：
Akil, Huda
影响因子：
2.7
作者：
DAVEY, GCL;CLELAND, GG
通讯作者：
CLELAND, GG
影响因子：
5.3
作者：
Mahler, Stephen V.;Berridge, Kent C.
通讯作者：
Berridge, Kent C.
伏隔核和基底外侧杏仁核的作用在Autoshaped Lever按压中。
影响因子：
2.7
作者：
Chang, Stephen E.;Wheeler, Daniel S.;Holland, Peter C.
通讯作者：
Holland, Peter C.
DOI：
10.1111/j.1460-9568.2010.07439.x
发表时间：
2010-11
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Shiflett MW;Balleine BW
通讯作者：
Balleine BW