Engineering cytokines and cytokine circuits.
Engineering cytokines and cytokine circuits.
复制标题
工程细胞因子和细胞因子电路。
DOI：
10.1126/science.abb5607
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发表时间：
2020-11-27
期刊：
影响因子：
--
通讯作者：
Lim WA
中科院分区：
文献类型：
--
作者：
Li AW;Lim WA
细胞因子对免疫细胞的行为具有深远的影响。鉴于其强大的作用，试图利用细胞因子作为癌症和其他疾病的治疗药物已有很长的历史。然而，有几个问题严重限制了细胞因子的治疗用途，包括它们的多效性作用和全身毒性。克服这些问题以创建下一代基于麻黄碱的疗法将需要对其时空功能进行复杂的控制。新的方法在蛋白质和细胞工程正在出现，允许不同的和多个层次的程序细胞因子的调节，从工程个别细胞因子，到精氨酸受体对，并最终，更复杂的精氨酸传感，分泌和消耗细胞电路。这些技术可以赋予精确塑造局部细胞因子环境的能力，并通过这样做，提高细胞因子药物的效力，加深我们对细胞因子通信语言的理解。
Cytokines have far-reaching effects on the behavior of immune cells. Given their powerful roles, there has been a long history of trying to harness cytokines as therapeutic drugs for cancer and other diseases. However, there are several problems that severely limit the therapeutic use of cytokines, including their pleiotropic actions and systemic toxicity. Overcoming these issues to create the next generation of cytokine-based therapies will require sophisticated control over their spatial-temporal function. New approaches in protein and cell engineering are emerging that allow distinct and multiple levels at which to program cytokine regulation—from engineering individual cytokines, to cytokine-receptor pairs, and ultimately, more complex cytokine-sensing, -secreting, and -consuming cell circuits. These technologies may confer the ability to precisely sculpt the local cytokine environment, and by doing so, improve the potency of cytokine drugs and deepen our understanding of the language of cytokine communication.
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影响因子：
4.6
作者：
Yeku OO;Purdon TJ;Koneru M;Spriggs D;Brentjens RJ
通讯作者：
Brentjens RJ
DOI：
10.1126/science.aar3246
发表时间：
2018-03-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Sockolosky JT;Trotta E;Parisi G;Picton L;Su LL;Le AC;Chhabra A;Silveria SL;George BM;King IC;Tiffany MR;Jude K;Sibener LV;Baker D;Shizuru JA;Ribas A;Bluestone JA;Garcia KC
通讯作者：
Garcia KC
影响因子：
11.5
作者：
Margolin, Kim;Atkins, Michael B.;Schwartz, Brian
通讯作者：
Schwartz, Brian
影响因子：
64.5
作者：
Roybal, Kole T.;Williams, Jasper Z.;Morsut, Leonardo;Rupp, Levi J.;Kolinko, Isabel;Choe, Joseph H.;Walker, Whitney J.;McNally, Krista A.;Lim, Wendell A.
通讯作者：
Lim, Wendell A.
影响因子：
32.4
作者：
Oyler-Yaniv A;Oyler-Yaniv J;Whitlock BM;Liu Z;Germain RN;Huse M;Altan-Bonnet G;Krichevsky O
通讯作者：
Krichevsky O