Ferritin for the clinician.

Ferritin for the clinician.
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供临床医生使用的铁蛋白。

DOI:
10.1016/j.blre.2008.08.001
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发表时间:
2009-05
期刊:
影响因子:
7.4
通讯作者:
Torti, Frank M.
Torti, Frank M.
中科院分区:
医学1区
文献类型:
--
作者:
Knovich, Mary Ann;Storey, Jonathan A.;Coffman, Lan G.;Torti, Suzy V.;Torti, Frank M.
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铁蛋白是一种重要的铁储存蛋白,是维持铁稳态所必需的,并参与多种生理和病理过程。在临床医学中,铁蛋白主要用作全身铁储备的血清标志物。在铁缺乏和超负荷的情况下,血清铁蛋白在诊断和管理中起着关键作用。血清和组织铁蛋白升高与冠状动脉疾病、恶性肿瘤和干细胞移植后不良结局有关。铁蛋白直接参与较不常见但具有潜在破坏性的人类疾病,包括铁粒幼细胞性贫血、神经退行性疾病和噬血细胞综合征。此外,最近的研究描述了铁蛋白独立于铁储存的新功能。
Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In clinical medicine, ferritin is predominantly utilized as a serum marker of total body iron stores. In cases of iron deficiency and overload, serum ferritin serves a critical role in both diagnosis and management. Elevated serum and tissue ferritin are linked to coronary artery disease, malignancy, and poor outcomes following stem cell transplantation. Ferritin is directly implicated in less common but potentially devastating human diseases including sideroblastic anemias, neurodegenerative disorders, and hemophagocytic syndrome. Additionally, recent research describes novel functions of ferritin independent of iron storage.
DOI: 10.1038/sj.bmt.1703570
发表时间: 2002-06-01
影响因子: 4.8
作者:
Altès, A;Remacha, AF;Gimferrer, E
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