Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature.
Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature.
复制标题
DOI：
10.1007/s40572-022-00371-7
复制
发表时间：
2022-12
影响因子：
7.9
通讯作者：
Kupsco, Allison
中科院分区：
文献类型：
--
作者：
Reddam, Aalekhya;McLarnan, Sarah;Kupsco, Allison
线粒体扮演着对细胞功能和生存至关重要的各种角色；因此，严重的线粒体功能障碍可能会产生超出细胞范围的慢性后果。线粒体已经很容易受到损伤，而环境暴露可能会加剧这种损伤。因此，本综述的目的是总结最近的文献(2012-2022年)，观察六种普遍存在的化合物对人类线粒体功能障碍的影响。文献表明，有许多生物标志物通常用于识别线粒体功能障碍，每一种都有一定的优势和局限性。多种环境毒物，如多环芳烃、空气污染物、重金属、干扰内分泌的化合物、杀虫剂和纳米材料，可以以不同的方式损害线粒体，线粒体DNA拷贝数的变化和氧化损伤的测量是人类最常测量的。其他重要的生物标志物包括线粒体膜电位、钙水平和三磷酸腺苷水平的变化。该综述确定了常用于表征线粒体功能障碍的生物标志物，但建议新兴的线粒体生物标志物，如无细胞线粒体和血心磷脂水平，可能会更好地了解暴露对线粒体功能的影响。这篇综述发现线粒体DNA拷贝数和氧化损伤的测量通常被用来表征线粒体功能障碍，但建议在充分表征线粒体功能障碍的方法之外使用新的方法来创建标准化的方案。我们发现，在暴露于金属、内分泌干扰化学品、杀虫剂和纳米颗粒的人群中，缺乏关于线粒体功能障碍的研究是一个需要关注的知识缺口。
Mitochondria play various roles that are important for cell function and survival; therefore, significant mitochondrial dysfunction may have chronic consequences that extend beyond the cell. Mitochondria are already susceptible to damage, which may be exacerbated by environmental exposures. Therefore, the aim of this review is to summarize the recent literature (2012–2022) looking at the effects of six ubiquitous classes of compounds on mitochondrial dysfunction in human populations. The literature suggests that there are a number of biomarkers that are commonly used to identify mitochondrial dysfunction, each with certain advantages and limitations. Classes of environmental toxicants such as polycyclic aromatic hydrocarbons, air pollutants, heavy metals, endocrine-disrupting compounds, pesticides, and nanomaterials can damage the mitochondria in varied ways, with changes in mtDNA copy number and measures of oxidative damage the most commonly measured in human populations. Other significant biomarkers include changes in mitochondrial membrane potential, calcium levels, and ATP levels. This review identifies the biomarkers that are commonly used to characterize mitochondrial dysfunction but suggests that emerging mitochondrial biomarkers, such as cell-free mitochondria and blood cardiolipin levels, may provide greater insight into the impacts of exposures on mitochondrial function. This review identifies that the mtDNA copy number and measures of oxidative damage are commonly used to characterize mitochondrial dysfunction, but suggests using novel approaches in addition to well-characterized ones to create standardized protocols. We identified a dearth of studies on mitochondrial dysfunction in human populations exposed to metals, endocrine-disrupting chemicals, pesticides, and nanoparticles as a gap in knowledge that needs attention.
登录
查看更多内容
DOI：
10.3390/life11090949
发表时间：
2021-09-10
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Acin-Perez R;Benincá C;Shabane B;Shirihai OS;Stiles L
通讯作者：
Stiles L
影响因子：
20.1
作者：
Bauer TM;Murphy E
通讯作者：
Murphy E
影响因子：
4.5
作者：
Blajszczak C;Bonini MG
通讯作者：
Bonini MG
影响因子：
3.2
作者：
Borchard, Sabine;Bork, Francesca;Zischka, Hans
通讯作者：
Zischka, Hans
影响因子：
5.5
作者：
Branca JJV;Pacini A;Gulisano M;Taddei N;Fiorillo C;Becatti M
通讯作者：
Becatti M