Hepatoprotective Effects of Swimming Exercise against D-Galactose-Induced Senescence Rat Model.
Hepatoprotective Effects of Swimming Exercise against D-Galactose-Induced Senescence Rat Model.
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DOI：
10.1155/2013/275431
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Lin WT
中科院分区：
文献类型：
--
作者：
Huang CC;Chiang WD;Huang WC;Huang CY;Hsu MC;Lin WT
本研究在大鼠实验性衰老模型中探讨了为期 12 周的游泳运动训练是否可以预防肝损伤或衰老相关生物标志物。将 23 只雄性 Sprague-Dawley 大鼠分为四组：用久坐控制进行载体治疗（C，n = 6），用久坐进行衰老诱导（A，n = 6），用游泳运动进行载体治疗（SW，n = 5），以及用游泳运动进行衰老诱导（A + SW，n = 6）。 A组和AS组大鼠腹腔注射d-半乳糖（150mg/kg/天）12周以诱导衰老。 SW组和A+SW组大鼠进行为期12周的游泳运动训练。实验结束时进行体重、肝脏重量、附睾脂肪量、血液生化和肝脏病理学检查。检查了肝脏衰老蛋白标志物，如 β-半乳糖苷酶、p53 和 p21，以及炎症介质 IL-6。与对照组相比，d-半乳糖治疗的大鼠血浆中 AST 和 γ-GT 水平以及 β-半乳糖苷酶蛋白表达有所增加。与衰老组相比，游泳运动显着降低了体重、附睾脂肪量、γ-GT 活性以及 p53、p21 和 IL-6 蛋白水平。这些结果表明，为期 12 周的游泳锻炼计划可抑制 d-半乳糖诱导的衰老大鼠肝组织中的衰老标志物并下调炎症介质。
This study investigates whether a 12-week swimming exercise training can prevent liver damage or senescence associated biomarkers in an experimental aging model in rats. Twenty-three male Sprague-Dawley rats were divided into four groups: vehicle treatment with sedentary control (C, n = 6), aging induction with sedentary (A, n = 6), vehicle treatment with swimming exercise (SW, n = 5), and aging induction with swimming exercise (A + SW, n = 6). Rats in groups A and AS received intraperitoneal d-galactose injections (150 mg/kg/day) for 12 weeks to induce aging. Rats in groups SW and A + SW were subjected to swimming exercise training for 12 weeks. Body weight, liver weight, epididymal fat mass, blood biochemistry, and liver pathology were performed at the end of the experiment. Hepatic senescence protein markers such as β-galactosidase, p53, and p21, as well as the inflammatory mediator, IL-6, were examined. The d-galactose-treated rats exhibited increases in AST and γ-GT plasma levels and β-galactosidase protein expression compared to the control group. Swimming exercise significantly reduced BW, epididymal fat mass, γ-GT activity, and p53, p21, and IL-6 protein levels compared to the aging group. These results suggest that a 12-week swimming exercise program suppresses senescence markers and downregulates inflammatory mediator in the liver tissues of d-galactose-induced aging rats.
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DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
2.7
作者：
Lu, Jun;Zheng, Yuan-lin;Feng, You-jian
通讯作者：
Feng, You-jian
影响因子：
2.6
作者：
Buemi, M;Nostro, L;Frisina, N
通讯作者：
Frisina, N
影响因子：
2.3
作者：
Gagliano, Nicoletta;Grizzi, Fabio;Annoni, Giorgio
通讯作者：
Annoni, Giorgio
影响因子：
56.9
作者：
Herbig, U;Ferreira, M;Sedivy, JM
通讯作者：
Sedivy, JM