Motility characteristics in the transition zone in Gastroesophageal Reflux Disease (GORD) patients.
Motility characteristics in the transition zone in Gastroesophageal Reflux Disease (GORD) patients.
复制标题
胃食管反流病（GORD）患者过渡区的运动特征
DOI：
10.1186/s12876-016-0525-1
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发表时间：
2016-08-30
影响因子：
2.4
通讯作者：
Xiao YL
中科院分区：
文献类型：
--
作者：
Li YW;Xie CX;Wu KM;Chen MH;Xiao YL
背景食管远端狭窄的缺陷被认为是不完全的食团传输（BT）的指征。然而，移行区（TZ）缺陷在胃食管反流病（GORD）患者BT中的作用需要澄清。本研究的目的是评估TZ缺陷GORD患者和探讨TZ缺陷和BT之间的关系。方法102例反流症状和20例健康成人纳入研究。所有受试者均接受上消化道内镜检查、高分辨率阻抗测压（HRiM）和24小时动态多通道阻抗pH（MII-pH）监测。根据MII-pH监测将患者分为反流性食管炎（RE）、非糜烂性反流病（NERD）、过敏性食管（HO）和功能性胃灼热（FH）。食管压力地形图进行了分析，以确定TZ缺陷的空间或时间TZ测量超过2厘米或1秒，弱和碎片吞咽被排除在外，和TZ和BT之间的关联进行了调查。（RE：1.75 s（1.32-2.17）和2.50 cm（2.40-3.20）; NERD：1.60 s（1.10-2.00）和2.20 cm（2.10-2.65）; HO：1.60 s FH：1.55 s（1.20-2.17）和3.10 cm（2.25-5.00）;健康志愿者：1.50 s（1.20-1.90）和2.30 cm（2.10-3.00）。然而，与没有TZ缺陷的个体相比，TZ缺陷的个体具有较低的完全BT率（p< 0.001）。RE、HO和FH患者的不完全BT也显著高于健康对照组（p< 0.05）。
BackgroundDefects in distal oesophageal peristalsis was thought to be an indication of incomplete bolus transit (BT). However, the role of transition zone (TZ) defects in the BT in gastroesophageal reflux disease (GORD) patients needs clarification. The aim of this study was to assess the TZ defects in GORD patients and to explore the relationship between TZ defects and BT.MethodsOne hundred and two patients with reflux symptoms and 20 healthy adults were included in the study. All subjects underwent upper gastrointestinal endoscopy, high resolution impedance manometry (HRiM) and 24-h ambulatory multichannel impedance-pH (MII-pH) monitoring. Patients were subgrouped into reflux oesophagitis (RE), non-erosive reflux disease (NERD), hypersensitive oesophagus (HO) and functional heartburn (FH) classified following MII-pH monitoring. Oesophageal pressure topography was analysed to define TZ defects by spatial or temporal TZ measurements exceeding 2 cm or 1 s, weak and fragmented swallows were excluded, and the association between TZ and BT was investigated.ResultsFollowing liquid swallows, there were no significant differences in TZ delay time and TZ length between groups (RE: 1.75 s (1.32–2.17) and 2.50 cm (2.40–3.20); NERD: 1.60 s (1.10–2.00) and 2.20 cm (2.10–2.65); HO: 1.60 s (1.30–1.80) and 2.70 cm (2.30–3.00); FH: 1.55 s (1.20–2.17) and 3.10 cm (2.25–5.00); Healthy volunteers: 1.50 s (1.20–1.90) and 2.30 cm (2.10–3.00). However, individuals with TZ defects had lower complete BT rates compared with those without TZ defects (p< 0.001). There were also significantly more incomplete BT in patients with RE, HO and FH than in healthy controls (p< 0.05).ConclusionsIn GORD patients, TZ defects correlated with proximal bolus retention in the corresponding area independent of distal weak peristalsis.
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影响因子：
3.4
作者：
Choi WS;Kim TW;Kim JH;Lee SH;Hur WJ;Choe YG;Lee SH;Park JH;Sohn CI
通讯作者：
Sohn CI
DOI：
10.1152/ajpgi.00510.2005
发表时间：
2006-05-01
影响因子：
4.5
作者：
Ghosh, SK;Pandolfino, JE;Kahrilas, PJ
通讯作者：
Kahrilas, PJ
影响因子：
2.9
作者：
Meyer, GW;Gerhardt, DC;Castell, DO
通讯作者：
Castell, DO
影响因子：
3.5
作者：
Ghosh SK;Pandolfino JE;Kwiatek MA;Kahrilas PJ
通讯作者：
Kahrilas PJ
影响因子：
9.8
作者：
Bulsiewicz, William J.;Kahrilas, Peter J.;Kwiatek, Monika A.;Ghosh, Sudip K.;Meek, Albert;Pandolfino, John E.
通讯作者：
Pandolfino, John E.