High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry.
High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry.
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DOI：
10.5056/jnm.2013.19.4.473
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发表时间：
2013-10
影响因子：
3.4
通讯作者：
Sohn CI
中科院分区：
文献类型：
--
作者：
Choi WS;Kim TW;Kim JH;Lee SH;Hur WJ;Choe YG;Lee SH;Park JH;Sohn CI
异物感是咽喉部的异物感，无吞咽困难、吞咽痛、食管动力障碍或胃食管反流。病因尚不清楚。既往研究认为上食管括约肌压力增高、胃食管反流和食管体部高渗是其可能的病因。本研究旨在通过对不伴胃食管反流病（GERD）患者和正常对照组的食管上括约肌（UES）压力、收缩波速度（CFV）、近端收缩积分（PCI）、远端收缩积分（DCI）和移行区（TZ）进行定量分析，探讨特异性高分辨率测压（HRM）结果与胃食管反流病（GERD）的相关性。自2009年以来，我们对57例球形症患者、24例GERD患者和7例正常对照者进行了HRM研究。我们审查了报告，并在每份报告中选择了5个适合分析的吞咽图，使用ManoView分析了每个单独的图。将57例胃球症患者与24例胃食管反流病患者及7例正常对照者的5项参数进行比较。UES压力、CFV、PCI和DCI无显著差异。与正常对照组和GERD患者相比，TZ（30 mmHg等压等值线）在球核中的分布有显著性差异。TZ的中位数在Globus患者中为4.26 cm（四分位距[IQR]，2.30-5.85），在GERD患者中为5.91 cm（IQR，3.97-7.62），在正常对照组中为2.26 cm（IQR，1.22-2.92）（P = 0.001）。HRM分析提示UES压力、CFV、PCI和DCI与球蛋白血症无关。相反，TZ长度的增加可能与球形相关。进一步的研究比较HRM结果在更大的人群中的球症患者需要确认他们的相关性。
Globus is a foreign body sense in the throat without dysphagia, odynophagia, esophageal motility disorders, or gastroesophageal reflux. The etiology is unclear. Previous studies suggested that increased upper esophageal sphincter pressure, gastroesophageal reflux and hypertonicity of esophageal body were possible etiologies. This study was to quantify the upper esophageal sphincter (UES) pressure, contractile front velocity (CFV), proximal contractile integral (PCI), distal contractile integral (DCI) and transition zone (TZ) in patient with globus gastroesophageal reflux disease (GERD) without globus, and normal controls to suggest the correlation of specific high-resolution manometry (HRM) findings and globus. Fifty-seven globus patients, 24 GERD patients and 7 normal controls were studied with HRM since 2009. We reviewed the reports, and selected 5 swallowing plots suitable for analysis in each report, analyzed each individual plot with ManoView. The 5 parameters from each plot in 57 globus patients were compared with that of 24 GERD patients and 7 normal controls. There was no significant difference in the UES pressure, CFV, PCI and DCI. TZ (using 30 mmHg isobaric contour) in globus showed significant difference compared with normal controls and GERD patients. The median values of TZ were 4.26 cm (interquartile range [IQR], 2.30-5.85) in globus patients, 5.91 cm (IQR, 3.97-7.62) in GERD patients and 2.26 cm (IQR, 1.22-2.92) in normal controls (P = 0.001). HRM analysis suggested that UES pressure, CFV, PCI and DCI were not associated with globus. Instead increased length of TZ may be correlated with globus. Further study comparing HRM results in globus patients within larger population needs to confirm their correlation.
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影响因子：
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作者：
Kwiatek, Monika A.;Mirza, Faiz;Kahrilas, Peter J.;Pandolfino, John E.
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DOI：
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