Spatial encoding and underlying circuitry in scene-selective cortex.
Spatial encoding and underlying circuitry in scene-selective cortex.
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DOI：
10.1016/j.neuroimage.2013.07.030
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发表时间：
2013-12
期刊：
影响因子：
5.7
通讯作者：
Tootell, Roger B. H.
中科院分区：
文献类型：
--
作者：
Nasr, Shahin;Devaney, Kathryn J.;Tootell, Roger B. H.
三个皮质区域（脾后皮质（RSC）、枕横沟（TOS）和海马旁区域（PPA））选择性地对场景做出反应。然而，它们在空间编码中的更广泛作用及其功能连接仍不清楚。首先，我们使用功能磁共振成像，使用白噪声上的点目标测试了这些区域在空间比较任务中的响应。 RSC 和 TOS 中的任务执行期间活动有所增加，但 PPA 中则没有。然而，任务驱动活动的幅度和任务需求的行为测量仅在 RSC 中相关。对照实验表明，在可比较的形状比较任务中，这些区域都没有被激活。其次，我们分析了这些区域在静息状态下的功能连接。结果显示 RSC 和额叶关联区域（已知参与知觉决策）之间存在显着联系。相比之下，TOS 在背侧显示出与顶下沟的功能连接，在腹侧显示与枕外侧复合体的功能连接，但与 RSC 和/或额叶关联区域没有功能连接。此外，RSC 和 TOS 分别显示出与 PPA 的前内侧和后外侧部分的可微功能连接。这些结果表明了空间编码的两条平行途径，分别包括 RSC 和 TOS。只有 RSC 网络参与主动空间比较。
Three cortical areas (Retro-Splenial Cortex (RSC), Transverse Occipital Sulcus (TOS) and Parahippocampal Place Area (PPA)) respond selectively to scenes. However, their wider role in spatial encoding and their functional connectivity remains unclear. Using fMRI, first we tested the responses of these areas during spatial comparison tasks using dot targets on white noise. Activity increased during task performance in both RSC and TOS, but not in PPA. However, the amplitude of task-driven activity and behavioral measures of task demand were correlated only in RSC. A control experiment showed that none of these areas were activated during a comparable shape comparison task. Secondly, we analyzed functional connectivity of these areas during the resting state. Results revealed a significant connection between RSC and frontal association areas (known to be involved in perceptual decision-making). In contrast, TOS showed functional connections dorsally with the Inferior Parietal Sulcus, and ventrally with the Lateral Occipital Complex - but not with RSC and/or frontal association areas. Moreover, RSC and TOS showed differentiable functional connections with the anterior-medial and posterior-lateral parts of PPA, respectively. These results suggest two parallel pathways for spatial encoding, including RSC and TOS respectively. Only the RSC network was involved in active spatial comparisons.
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