Differential connectivity within the Parahippocampal Place Area.
Differential connectivity within the Parahippocampal Place Area.
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DOI：
10.1016/j.neuroimage.2013.02.073
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发表时间：
2013-07-15
期刊：
影响因子：
5.7
通讯作者：
Fei-Fei, Li
中科院分区：
文献类型：
--
作者：
Baldassano, Christopher;Beck, Diane M.;Fei-Fei, Li
传统上，海马旁区域(PPA)被认为是一个同质的感兴趣区，但最近来自人类研究和动物模型的证据表明，PPA可能由功能不同的亚单位组成。为了研究这一假设，我们利用了一种功能连接性测量方法，可以在体素水平上估计连接性差异。将这种方法应用于两个实验的全脑数据，我们提供了第一个直接证据，表明前部和后部PPA显示出不同的连接模式，其中前部PPA与默认模式网络中的区域(包括顶侧-内侧颞叶通路)的连接更强烈，而后部PPA与枕叶视觉区域的连接更强。我们发现，PPA的物体敏感性也有一个前后梯度，在后PPA中对抽象物体的反应更强。这些发现对PPA作为单一连贯区域的传统观点提出了质疑，并表明PPA由一个专门处理低水平视觉特征和物体形状的子区和一个更涉及记忆和场景背景的单独子区组成。
The Parahippocampal Place Area (PPA) has traditionally been considered a homogeneous region of interest, but recent evidence from both human studies and animal models has suggested that PPA may be composed of functionally distinct subunits. To investigate this hypothesis, we utilize a functional connectivity measure for fMRI that can estimate connectivity differences at the voxel level. Applying this method to whole-brain data from two experiments, we provide the first direct evidence that anterior and posterior PPA exhibit distinct connectivity patterns, with anterior PPA more strongly connected to regions in the default mode network (including the parieto-medial temporal pathway) and posterior PPA more strongly connected to occipital visual regions. We show that object sensitivity in PPA also has an anterior-posterior gradient, with stronger responses to abstract objects in posterior PPA. These findings cast doubt on the traditional view of PPA as a single coherent region, and suggest that PPA is composed of one subregion specialized for the processing of low-level visual features and object shape, and a separate subregion more involved in memory and scene context.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
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