Exercise and time-dependent benefits to learning and memory.
Exercise and time-dependent benefits to learning and memory.
复制标题
DOI：
10.1016/j.neuroscience.2010.02.050
复制
发表时间：
2010-05-19
期刊：
影响因子：
3.3
通讯作者：
Cotman, C. W.
中科院分区：
文献类型：
--
作者：
Berchtold, N. C.;Castello, N.;Cotman, C. W.
虽然运动可以改善认知能力已经得到了很好的证实，但目前还不清楚这些好处在运动结束后能持续多久。因此，自愿运动对认知功能和脑源性神经营养因子（BDNF）蛋白水平的影响，在记忆形成和储存的动态机制中的主要参与者，在3周的跑步期后立即进行评估，或在运动期后延迟1周或2周后进行评估。相对于久坐的动物，所有运动的小鼠在径向臂水迷宫上表现出改善的表现。出乎意料的是，最快的收购（最少的错误和最短的潜伏期）发生在动物训练后1周的延迟，而最好的记忆表现在探针试验中观察到那些训练后立即运动期。对运动后海马BDNF可用性的时间过程的评估显示，运动后即刻（静坐水平的186%）以及运动结束后1周和2周，BDNF显著升高，3-4周后水平恢复到基线水平。BDNF蛋白水平与放射状水迷宫训练中的认知改善和第4天的记忆表现呈正相关，支持BDNF可用性有助于本研究中揭示的运动的时间依赖性认知益处的观点。总的来说，这种评估运动认知和生物化学效应的时间耐力的新方法揭示了运动学习领域的新概念，并揭示了运动对大脑可塑性的有益影响即使在运动结束后也会继续发展。
While it is well established that exercise can improve cognitive performance, it is unclear how long these benefits endure after exercise has ended. Accordingly, the effects of voluntary exercise on cognitive function and brain-derived neurotrophic factor (BDNF) protein levels, a major player in the mechanisms governing the dynamics of memory formation and storage, were assessed immediately after a 3-week running period, or after a 1-week or 2-week delay following the exercise period. All exercised mice showed improved performance on the radial arm water maze relative to sedentary animals. Unexpectedly, fastest acquisition (fewest errors and shortest latency) occurred in animals trained following a 1-week delay, while best memory performance in the probe trial was observed in those trained immediately after the exercise period. Assessment of the time course of hippocampal BDNF availability following exercise revealed significant elevations of BDNF immediately after the exercise period (186% of sedentary levels) and at 1 and 2 weeks after exercise ended, with levels returning to baseline by 3–4 weeks. BDNF protein levels showed a positive correlation with cognitive improvement in radial water maze training and with memory performance on day 4, supporting the idea that BDNF availability contributes to the time-dependent cognitive benefits of exercise revealed in this study. Overall, this novel approach assessing the temporal endurance of cognitive and biochemical effects of exercise unveils new concepts in the exercise-learning field, and reveals that beneficial effects of exercise on brain plasticity continue to evolve even after exercise has ended.
登录
查看更多内容
影响因子：
2.1
作者：
Ding, Yun-Hong;Li, Jie;Ding, Yuchuan
通讯作者：
Ding, Yuchuan
影响因子：
18.4
作者：
Erickson KI;Kramer AF
通讯作者：
Kramer AF
DOI：
10.1016/j.jalz.2009.02.006
发表时间：
2009-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Nichol K;Deeny SP;Seif J;Camaclang K;Cotman CW
通讯作者：
Cotman CW
影响因子：
39.2
作者：
Larson, EB;Wang, L;Kukull, W
通讯作者：
Kukull, W
影响因子：
3.4
作者：
Molteni, R;Ying, Z;Gómez-Pinilla, F
通讯作者：
Gómez-Pinilla, F