Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection.
Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection.
复制标题
DOI：
10.1084/jem.20100479
复制
发表时间：
2011-02-14
期刊：
影响因子：
--
通讯作者：
Lanier LL
中科院分区：
文献类型：
--
作者：
Sun JC;Beilke JN;Bezman NA;Lanier LL
Like memory T cells, natural killer cells that undergo homeostatic expansion in mice self-renew and retain the ability to respond to subsequent viral infection. Cells of the immune system undergo homeostatic proliferation during times of lymphopenia induced by certain viral infections or caused by chemotherapy and radiation treatment. Natural killer (NK) cells are no exception and can rapidly expand in number when placed into an environment devoid of these cells. We explored the lifespan and function of mouse NK cells that have undergone homeostatic proliferation in various settings of immunodeficiency. Adoptive transfer of mature NK cells into lymphopenic mice resulted in the generation of a long-lived population of NK cells. These homeostasis-driven NK cells reside in both lymphoid and nonlymphoid organs for >6 mo and, similar to memory T cells, self-renew and slowly turn over at steady state. Furthermore, homeostatically expanded NK cells retained their functionality many months after initial transfer and responded robustly to viral infection. These findings highlight the ability of mature NK cells to self-renew and possibly persist in the host for months or years and might be of clinical importance during NK cell adoptive immunotherapy for the treatment of certain cancers.
登录
查看更多内容
影响因子：
32.4
作者：
Ernst, B;Lee, DS;Surh, CD
通讯作者：
Surh, CD
影响因子：
15.3
作者：
Goldrath, Ananda W;Sivakumar, Pallavur V;Glaccum, Moira;Kennedy, Mary K;Bevan, Michael J;Benoist, Christophe;Mathis, Diane;Butz, Eric A
通讯作者：
Butz, Eric A
DOI：
10.1016/j.bbmt.2009.01.019
发表时间：
2009-07
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Gill S;Olson JA;Negrin RS
通讯作者：
Negrin RS
影响因子：
32.4
作者：
Correia-Neves, M;Waltzinger, C;Benoist, C
通讯作者：
Benoist, C
影响因子：
82.9
作者：
Hellerstein, M;Hanley, MB;McCune, JM
通讯作者：
McCune, JM