Coffee Consumption and Risk of Dementia and Alzheimer's Disease: A Dose-Response Meta-Analysis of Prospective Studies.
Coffee Consumption and Risk of Dementia and Alzheimer's Disease: A Dose-Response Meta-Analysis of Prospective Studies.
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DOI：
10.3390/nu10101501
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发表时间：
2018-10-14
期刊：
影响因子：
5.9
通讯作者：
Orsini N
中科院分区：
文献类型：
--
作者：
Larsson SC;Orsini N
咖啡消费与几种疾病的风险降低有关，但咖啡消费对痴呆症风险的影响仍然不确定。我们进行了一项剂量反应荟萃分析，总结了咖啡消费与痴呆和阿尔茨海默病相关风险的前瞻性数据。我们通过检索PubMed（从1966年1月起）和Web of Science（从1945年1月起）到2018年10月4日，并通过审查相关出版物的参考文献列表来识别研究。两名研究人员独立审查了文献。使用基于一阶段方法的限制性三次样条随机效应剂量反应荟萃分析合并结果。确定了8项相关前瞻性研究。这些研究包括在平均4.9-25年的随访期间在328，885人中诊断出的7486例痴呆症病例。对所有8项研究的荟萃分析表明，咖啡摄入量与痴呆症风险之间没有统计学显著相关性，也没有偏离线性趋势（p = 0.08）。每增加1杯/天的咖啡摄入量，痴呆的相对风险为1.01（95%置信区间（CI）0.98-1.05; p = 0.37）。对五项针对阿尔茨海默病的研究进行的荟萃分析显示，咖啡消费与阿尔茨海默病之间没有关联，也没有偏离线性趋势（p = 0.79）。每增加1杯/天的咖啡摄入量，患阿尔茨海默病的相对风险为1.01（95%置信区间为0.95-1.07; p = 0.80）。这些结果并不支持咖啡消费与整体痴呆症或阿尔茨海默病风险增加之间的关联，但需要进一步研究咖啡消费与痴呆症风险之间的关联。
Coffee consumption is associated with a reduced risk of several diseases but uncertainty remains about the influence of coffee consumption on the risk of dementia. We performed a dose-response meta-analysis to summarize the prospective data on coffee consumption and associated risk of dementia and Alzheimer’s disease. We identified studies by searching PubMed (from January 1966) and Web of Science (from January 1945) through 4 October 2018 and by scrutinizing the reference lists of pertinent publications. Two researchers independently reviewed the literature. Results were combined using a restricted cubic spline random-effects dose-response meta-analysis based on a one-stage approach. Eight relevant prospective studies were identified. These studies included 7486 dementia cases diagnosed among 328,885 individuals during an average follow-up of 4.9–25 years. Meta-analysis of all eight studies indicated no statistically significant association between coffee consumption and the risk of dementia and no deviations from a linear trend (p = 0.08). The relative risk of dementia per 1 cup/day increment of coffee consumption was 1.01 (95% confidence interval (CI) 0.98–1.05; p = 0.37). Meta-analysis of five studies that focused on Alzheimer’s disease revealed no association between coffee consumption and Alzheimer’s disease and no deviations from a linear trend (p = 0.79). The relative risk of Alzheimer’s disease per 1 cup/day increment of coffee consumption was 1.01 (95% confidence interval 0.95–1.07; p = 0.80). These results do not support an association between coffee consumption and an increased risk of overall dementia or Alzheimer’s disease specifically, but further research on the association of coffee consumption with dementia risk is needed.
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影响因子：
3.7
作者：
Noguchi-Shinohara M;Yuki S;Dohmoto C;Ikeda Y;Samuraki M;Iwasa K;Yokogawa M;Asai K;Komai K;Nakamura H;Yamada M
通讯作者：
Yamada M
影响因子：
39.2
作者：
Park SY;Freedman ND;Haiman CA;Le Marchand L;Wilkens LR;Setiawan VW
通讯作者：
Setiawan VW
DOI：
10.3233/jad-2009-1071
发表时间：
2009
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Cao C;Cirrito JR;Lin X;Wang L;Verges DK;Dickson A;Mamcarz M;Zhang C;Mori T;Arendash GW;Holtzman DM;Potter H
通讯作者：
Potter H
影响因子：
14
作者：
通讯作者：
--
影响因子：
5
作者：
Loftfield, Erikka;Freedman, Neal D.;Sinha, Rashmi
通讯作者：
Sinha, Rashmi