Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.
Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.
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DOI：
10.1371/journal.pone.0096013
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yamada M
中科院分区：
文献类型：
--
作者：
Noguchi-Shinohara M;Yuki S;Dohmoto C;Ikeda Y;Samuraki M;Iwasa K;Yokogawa M;Asai K;Komai K;Nakamura H;Yamada M
我们的目的是确定饮用绿色茶、咖啡或红茶是否会影响老年人痴呆和轻度认知障碍（MCI）的发病率。我们对来自日本中岛的年龄>60岁的日本居民进行了一项基于人群的前瞻性研究（中岛项目）。参与者接受了认知功能和血液测试的评估。还在基线时评估了绿色茶、咖啡和红茶的消耗量。在基线调查（2007-2008年）时认知功能正常的723名参与者中，有490人在2011-2013年完成了随访调查。随访期间（平均值± SD：4.9±0.9年）痴呆的发生率为5.3%，MCI的发生率为13.1%。与完全不喝绿色茶的人相比，每天喝绿色茶的人总体认知能力下降（痴呆或MCI）发生率的多重校正比值比为0.32（95% CI：0.16-0.64），每周喝绿色茶1-6天的人为0.47（95% CI：0.25-0.86）。与完全不喝绿色茶的人相比，每天喝绿色茶的人痴呆发病率的多重调整优势比为0.26（95%CI：0.06-1.06）。没有发现咖啡或红茶消费与痴呆症或MCI的发病率之间存在关联。我们的研究结果表明，绿色茶的消费与认知能力下降的风险降低显着相关，即使在调整可能的混杂因素。
Our objective was to determine whether the consumption of green tea, coffee, or black tea influences the incidence of dementia and mild cognitive impairment (MCI) in older people. We conducted a population-based prospective study with Japanese residents aged >60 years from Nakajima, Japan (the Nakajima Project). Participants received an evaluation of cognitive function and blood tests. The consumption of green tea, coffee, and black tea was also evaluated at baseline. Of 723 participants with normal cognitive function at a baseline survey (2007–2008), 490 completed the follow up survey in 2011–2013. The incidence of dementia during the follow-up period (mean ± SD: 4.9±0.9 years) was 5.3%, and that of MCI was 13.1%. The multiple-adjusted odds ratio for the incidence of overall cognitive decline (dementia or MCI) was 0.32 (95% CI: 0.16–0.64) among individuals who consumed green tea every day and 0.47 (95% CI: 0.25–0.86) among those who consumed green tea 1–6 days per week compared with individuals who did not consume green tea at all. The multiple-adjusted odds ratio for the incidence of dementia was 0.26 (95% CI: 0.06–1.06) among individuals who consumed green tea every day compared with those who did not consume green tea at all. No association was found between coffee or black tea consumption and the incidence of dementia or MCI. Our results indicate that green tea consumption is significantly associated with reduced risk of cognitive decline, even after adjustment for possible confounding factors.
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