Some highlights of research on aging with invertebrates, 2010.
Some highlights of research on aging with invertebrates, 2010.
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关于无脊椎动物衰老的研究的一些亮点，2010年。
DOI：
10.1111/j.1474-9726.2010.00649.x
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发表时间：
2011-02
期刊：
影响因子：
7.8
通讯作者：
Partridge L
中科院分区：
文献类型：
--
作者：
Partridge L
这份年度综述的重点是无脊椎动物模型生物，它们继续为衰老机制提供基本的新见解。今年，萌芽酵母被用来理解细胞分裂时细胞成分的不对称分配如何从老化的父母那里产生恢复活力的后代。阻断二氧化碳的感觉被证明可以延长苍蝇的寿命，并调节感官暴露在发酵酵母中的缩短寿命的效果。对秀丽线虫胰岛素信号通路中关键的叉头转录因子daf-16的一项新研究表明，对上游信号具有不同响应模式的组织特异性异构体的表达介导了该通路对寿命和其他特征的高度多效性效应。一种通过引入酵母NADH-泛醌氧化还原酶来控制果蝇线粒体活性的新方法，显示了理解线粒体活性氧物种在衰老中的作用的希望。对酵母和哺乳动物细胞的一项令人兴奋的新研究表明，核孔的恶化，以及随之而来的细胞质成分渗入细胞核，是有丝分裂后组织衰老的重要原因。染色体相关组蛋白的丢失或损伤也与酵母、蠕虫和果蝇的寿命测定有关。在线虫中的两项研究中探索了功能老化、对衰老相关疾病的易感性和寿命本身之间的关系，第一项研究探讨了饮食限制和胰岛素信号减少在认知下降中的作用，第二项研究了蛋白质组在衰老过程中的聚集情况。无脊椎动物仍然是哺乳动物未来工作的发源地。
This annual review focuses on invertebrate model organisms, which continue to yield fundamental new insights into mechanisms of aging. This year, the budding yeast has been used to understand how asymmetrical partitioning of cellular constituents at cell division can produce a rejuvenated offspring from an aging parent. Blocking of sensation of carbon dioxide is shown to extend fly lifespan and to mediate the lifespan-shortening effect of sensory exposure to fermenting yeast. A new study of daf-16, the key forkhead transcription factor that mediates extension of lifespan by mutants in the insulin-signalling pathway in Caenorhabditis elegans, demonstrates that expression of tissue-specific isoforms with different patterns of response to upstream signalling mediates the highly pleiotropic effects of the pathway on lifespan and other traits. A new approach to manipulating mitochondrial activity in Drosophila, by introducing the yeast NADH-ubiquinone oxidoreductase, shows promise for understanding the role of mitochondrial reactive oxygen species in aging. An exciting new study of yeast and mammalian cells implicates deterioration of the nuclear pore, and consequent leakage of cytoplasmic components into the nucleus, as an important cause of aging in postmitotic tissues. Loss of, or damage to, chromosome-associated histones is also implicated in the determination of lifespan in yeast, worms and fruit flies. The relationship between functional aging, susceptibility to aging-related disease and lifespan itself are explored in two studies in C. elegans, the first examining the role of dietary restriction and reduced insulin signalling in cognitive decline and the second profiling aggregation of the proteome during aging. The invertebrates continue to be a power house of discovery for future work in mammals.
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影响因子：
5.2
作者：
Greer EL;Banko MR;Brunet A
通讯作者：
Brunet A
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
9.8
作者：
David DC;Ollikainen N;Trinidad JC;Cary MP;Burlingame AL;Kenyon C
通讯作者：
Kenyon C
影响因子：
29
作者：
Kapahi P;Chen D;Rogers AN;Katewa SD;Li PW;Thomas EL;Kockel L
通讯作者：
Kockel L
影响因子：
7.8
作者：
Bhandari, Poonam;Jones, Melanie A.;Grotewiel, Michael S.
通讯作者：
Grotewiel, Michael S.