Allergen-specific T lymphocytes as targets for specific immunotherapy: striking at the roots of type I allergy.
Allergen-specific T lymphocytes as targets for specific immunotherapy: striking at the roots of type I allergy.
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过敏原特异性 T 淋巴细胞作为特异性免疫治疗的靶标：直击 I 型过敏的根源。
DOI：
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发表时间：
2002
影响因子：
3.2
通讯作者：
B. Bohle
中科院分区：
文献类型：
--
作者：
B. Bohle
In the past decades allergic diseases have tremendously increased and hypersensitivity reactions represent a growing health concern in industrialized countries. Despite various effective therapeutic options for the treatment of allergic diseases, only specific immunotherapy (SIT) has been shown to have effects on the underlying immunological mechanisms, namely functional changes at the level of T helper (Th) lymphocytes. It was found that allergen-specific CD4+ Th2 lymphocytes play a key role in the pathophysiology of atopic diseases. During successful SIT, the Th2-dominated immune response is modified towards a Th1 response, leading to a decline in allergen-specific IgE levels in the long term. In order to improve the efficacy and safety of SIT, novel approaches were developed targeting allergen-specific Th2 lymphocytes since specific inactivation or modulation towards Th1 cells could interfere with the disease process. In view of this aspect, this review will basically focus on two new, promising approaches to improve SIT: (1) the use of hypoallergenic proteins characterized by reduced IgE-binding capacities but retained T lymphocyte-activating properties and (2) oligodeoxynucleotides containing CpG motifs as an example of adjuvants which foster Th1 immune responses. Both approaches promise to be capable of adjusting the pathological Th2 immune response.
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免疫刺激 DNA 抑制人类 B 细胞依赖 IL-4 的 IgE 合成。
DOI：
10.1067/mai.2001.117795
发表时间：
2001
期刊：
The Journal of allergy and clinical immunology.
影响因子：
--
作者：
Horner,AA;Widhopf,GF;Burger,JA;Takabayashi,K;Cinman,N;Ronaghy,A;Spiegelberg,HL;Raz,E
通讯作者：
Raz,E
黑麦草过敏原黑麦草 I 特异性人 T 细胞克隆对 T 细胞表位和淋巴因子分泌的识别。
DOI：
--
发表时间：
1994
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Spiegelberg,HL;Beck,L;Stevenson,DD;Ishioka,GY
通讯作者：
Ishioka,GY
DOI：
10.1073/pnas.93.7.2879
发表时间：
1996-04-02
影响因子：
11.1
作者：
Klinman, DM;Yi, AK;Krieg, AM
通讯作者：
Krieg, AM
影响因子：
4.4
作者：
Martin-Orozco, E;Kobayashi, H;Raz, E
通讯作者：
Raz, E
与 Amb a 1 过敏原相连的免疫刺激序列 DNA 可促进豚草过敏患者 PBMC 中 T(H)1 细胞因子的表达，同时下调 T(H)2 细胞因子的表达。
DOI：
10.1067/mai.2001.116984
发表时间：
2001
期刊：
The Journal of allergy and clinical immunology.
影响因子：
--
作者：
Marshall,JD;Abtahi,S;Eiden,JJ;Tuck,S;Milley,R;Haycock,F;Reid,MJ;Kagey-Sobotka,A;Creticos,PS;Lichtenstein,LM;VanNest,G
通讯作者：
VanNest,G