Research advances and applications of nucleic acid-modified techniques for biomedical nanomaterial
Research advances and applications of nucleic acid-modified techniques for biomedical nanomaterial
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生物医用纳米材料核酸修饰技术的研究进展及应用
DOI：
10.1016/j.jallcom.2018.01.251
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发表时间：
2018-04
影响因子：
6.2
通讯作者：
Fan HM
中科院分区：
文献类型：
--
作者：
Zhang N;Ma P;Xu SX;Fan A;Zhao YL;Xue WM;Luo YE;Fan HM
功能纳米粒子在严重疾病的精确诊断和最佳治疗方面具有巨大的潜力。然而，它们的应用受到结构异质性和物理性质、载药效率低、缺乏有效药物释放以及一些未确定的生理生化性质的限制。有效的表面修饰能够克服这些局限性，大大提高功能纳米粒子在生物医学中的应用性能。然而，使用常规表面活性剂进行化学或物理表面修饰很难确保纳米粒子在体内的均匀结构和正常代谢。该领域的最新进展表明，核酸修饰的纳米颗粒可以实现高效运输、稳态和合理代谢，以及明确的靶向性和可控的药物释放。所有这些优点都归功于核酸特殊的空间结构、同源性和生物学功能。此外，核酸骨架上丰富的活性位点不仅有利于纳米颗粒的直接或间接连接，而且有助于保留纳米颗粒本身和核酸的功能。在这篇综述中，我们总结了核酸修饰纳米粒子各自的突出特点和前景。此外，还重点介绍了制备核酸修饰纳米颗粒的主要表面修饰技术，包括非支架介导的修饰和支架介导的修饰。此外，还详细讨论了纳米颗粒和核酸之间的相互作用，以及修饰技术对核酸修饰纳米颗粒性质的影响。
Functional nanoparticles possess great potential for precise diagnosis and optimum therapy of serious diseases. However, their application is limited by structural heterogeneity and physical properties, low drug-loading efficiency, the absence of effective drug release, and some undetermined physiological and biochemical properties. Effective surface modification is able to overcome these limitations and largely improve the application performance of functional nanoparticles in biomedicine. Nevertheless, chemical or physical surface modifications using conventional surfactants are difficult to ensure homogeneous construction and normal metabolism of nanoparticlesin vivo. Recent progress in this field has demonstrated that nucleic acid-modified nanoparticles can attain efficient transport, steady state and rational metabolism, as well as clear targeting and controllable drug release. All of these advantages are attributed to the special steric structure, homology, and biological functions of nucleic acids. Moreover, abundant active sites on the nucleic acid skeleton not only facilitate the direct or indirect connection of nanoparticles, but also support retention of the functions of both nanoparticles themselves and nucleic acids. In this review, we summarize the outstanding respective characteristics and prospects of nucleic acid-modified nanoparticles. In addition, primary surface modification techniques for preparing nucleic acid-modified nanoparticles, including non-scaffold-mediated modification and scaffold-mediated modification, were highlighted. Furthermore, interactions between nanoparticles and nucleic acids, as well as the effects of modification techniques on the properties of nucleic acid modified nanoparticles, are discussed in detail.
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DOI：
10.1109/memsys.2003.1189672
发表时间：
2003-04
期刊：
The Sixteenth Annual International Conference on Micro Electro Mechanical Systems, 2003. MEMS-03 Kyoto. IEEE
影响因子：
--
作者：
T. Kawai
通讯作者：
T. Kawai
影响因子：
6.7
作者：
Anirban Samanta;Saswata Banerjee;Yan Liu
通讯作者：
Anirban Samanta;Saswata Banerjee;Yan Liu
影响因子：
6.6
作者：
Kozielski KL;Rui Y;Green JJ
通讯作者：
Green JJ
通过简便的方法增强疏水性胶体ZnO纳米颗粒的荧光成像性能
影响因子：
6.2
作者：
Zhigang Zang;Xiaosheng Tang
通讯作者：
Xiaosheng Tang
影响因子：
16.1
作者：
Au JL;Yeung BZ;Wientjes MG;Lu Z;Wientjes MG
通讯作者：
Wientjes MG