Phyllodes tumours of the breast: a consensus review.
Phyllodes tumours of the breast: a consensus review.
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DOI：
10.1111/his.12876
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发表时间：
2016-01
期刊：
影响因子：
6.4
通讯作者：
Tan PH
中科院分区：
文献类型：
--
作者：
Tan BY;Acs G;Apple SK;Badve S;Bleiweiss IJ;Brogi E;Calvo JP;Dabbs DJ;Ellis IO;Eusebi V;Farshid G;Fox SB;Ichihara S;Lakhani SR;Rakha EA;Reis-Filho JS;Richardson AL;Sahin A;Schmitt FC;Schnitt SJ;Siziopikou KP;Soares FA;Tse GM;Vincent-Salomon A;Tan PH
叶状肿瘤是一种少见但复杂的乳腺纤维上皮病变。由于需要评估多个分层的组织学参数，这些肿瘤的准确和可重复的分级长期以来一直是具有挑战性的，这些参数可能由各个病理学家进行不同的加权。由于显微镜下特征重叠，良性叶状肿瘤与细胞性纤维腺瘤的区分充满困难。同样，将恶性叶状肿瘤与梭形细胞化生癌和原发性乳腺肉瘤分开也是有问题的。叶状肿瘤通过手术切除治疗。然而，在确定适当的手术切缘以确保切除的完整性和降低复发风险方面没有达成共识。解释的主观性，重叠的组织学诊断标准，次优的组织学分类和临床行为之间的相关性和缺乏强大的分子预测的结果，使这些迷人的肿瘤的发病机制的进一步调查的积极研究的问题。这篇综述巩固了目前对它们的病理生物学和临床行为的理解，并包括对叶状肿瘤的分类和管理的合理方法的建议。
Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours.
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影响因子：
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作者：
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通讯作者：
Barth, RJ
DOI：
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发表时间：
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