Uric acid metabolism modulates diet-dependent responses to intraspecific competition in Drosophila larvae.
Uric acid metabolism modulates diet-dependent responses to intraspecific competition in Drosophila larvae.
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DOI：
10.1016/j.isci.2022.105598
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发表时间：
2022-12-22
期刊：
影响因子：
5.8
通讯作者：
Morimoto, Juliano
中科院分区：
文献类型：
--
作者：
Morimoto, Juliano
种内竞争推动生态专业化和生态位扩张。在全变异昆虫中，幼虫种内竞争（“拥挤”）对个体具有持久的适应性后果，并形成适应性反应。然而，我们对幼虫拥挤反应的分子特征的理解仍然是暗示的。在这里，我使用了尿酸代谢紊乱（uro -）的黑腹果蝇的遗传结构来证明尿酸代谢及其与幼虫聚集、饮食和尿素浓度的相互作用对雌性产卵和幼虫发育的作用。Uro -幼虫在富含糖的饮食中发育得更快。然而，在拥挤的幼虫条件下，在富含蛋白质和糖的饲料中，uro -幼虫在较低的高度化蛹，在富含蛋白质的混合基因型环境中发育较慢。Uro -不影响雌性产卵和幼虫化蛹的成功。总的来说，这项研究为全面理解全变异昆虫对种内竞争反应的分子途径提供了第一步。昆虫的尿酸代谢（UAM）受幼虫拥挤和饮食调节，导致果蝇成虫尿酸的生理积累，对雌性产卵没有影响，导致幼虫拥挤的饮食依赖性反应；生物科学;发育生物学。
Intraspecific competition drives ecological specialization, and niche expansion. In holometabolous insects, larval intraspecific competition (“crowding”) has lasting fitness consequences for individuals and shapes adaptive responses. However, our understanding of the molecular profile of larval crowding responses remains allusive. Here, I used a genetic construct in Drosophila melanogaster with disrupted uric acid metabolism (uro−) to demonstrate the role of the uric acid metabolism—and its interactive effects with larval crowding, diet, and urea concentration—on female oviposition and larval development. Uro− larvae developed faster in sugar-rich diets. However, uro− larvae pupated at lower heights in protein- and sugar-rich diets in crowded larval conditions and showed slower development in protein-rich mixed-genotype environments. uro− did not affect female oviposition nor larval pupation success. Overall, this study provides the first step toward an integrated understanding of the molecular pathways underpinning the responses to intraspecific competition in holometabolous insects. Uric acid metabolism (UAM) is modulated by larval crowding and diet in insects UAM disruption led to the physiological accumulation of uric acid in Drosophila adults UAM disruption had no effect on female oviposition UAM disruption led to diet-dependent responses to larval crowding Ecology; Biological sciences; Developmental biology.
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