Hypoxia-inducible factor-1α regulation of myeloid cells.
Hypoxia-inducible factor-1α regulation of myeloid cells.
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DOI：
10.1007/s00109-018-1710-1
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Bohannon JK
中科院分区：
文献类型：
--
作者：
Stothers CL;Luan L;Fensterheim BA;Bohannon JK
造血髓母细胞产生巨噬细胞、树突状细胞和中性粒细胞。循环骨髓细胞利用模式识别受体检测入侵的微生物，随后协调先天免疫反应来遏制和杀死病原体。这种先天免疫反应建立了一个炎症生态位，其特征是由于宿主和病原体因素引起的缺氧。缺氧诱导因子（HIF）转录因子是髓细胞对缺氧反应的主要调节因子。特别是，HIF-1α是感染或炎症期间整合缺氧和免疫原性信号的关键枢纽。缺氧诱导HIF-1α稳定，从而驱动骨髓细胞的代谢和表型重编程，以最大限度地发挥抗菌潜力。髓源性细胞中的HIF-1α活性增强了宿主对感染的反应，但也可能在致病性炎症过程（如动脉粥样硬化）中发挥作用。在这篇综述中，我们总结了近年来阐明髓细胞调节HIF-1α活性的机制以及HIF-1α如何影响髓细胞功能的研究进展。
Hematopoietic myeloblasts give rise to macrophages, dendritic cells, and neutrophils. Circulating myeloid cells detect invading microbes using pattern recognition receptors and subsequently orchestrate an innate immune response to contain and kill the pathogens. This innate immune response establishes an inflammatory niche characterized by hypoxia due to host and pathogen factors. Hypoxia-inducible factor (HIF) transcription factors are the primary regulators of the myeloid response to hypoxia. In particular, HIF-1α is a critical hub that integrates hypoxic and immunogenic signals during infection or inflammation. Hypoxia induces HIF-1α stabilization, which drives metabolic and phenotypic reprogramming of myeloid cells to maximize antimicrobial potential. HIF-1α activity in myeloid-derived cells enhances the host response to infection but may also play a role in pathogenic inflammatory processes such as atherosclerosis. In this review, we summarize recent advances that have elucidated the mechanism by which myeloid cells regulate HIF-1α activity and, in turn, how HIF-1α shapes myeloid cell function.
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影响因子：
5.3
作者：
Asplund, Annika;Friden, Vincent;Bondjers, Goran
通讯作者：
Bondjers, Goran
影响因子：
64.5
作者：
Bekkering, Siroon;Arts, Rob J. W.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
7.3
作者：
De Kleer I;Willems F;Lambrecht B;Goriely S
通讯作者：
Goriely S
影响因子：
29
作者：
Arts RJ;Novakovic B;Ter Horst R;Carvalho A;Bekkering S;Lachmandas E;Rodrigues F;Silvestre R;Cheng SC;Wang SY;Habibi E;Gonçalves LG;Mesquita I;Cunha C;van Laarhoven A;van de Veerdonk FL;Williams DL;van der Meer JW;Logie C;O'Neill LA;Dinarello CA;Riksen NP;van Crevel R;Clish C;Notebaart RA;Joosten LA;Stunnenberg HG;Xavier RJ;Netea MG
通讯作者：
Netea MG
影响因子：
15.9
作者：
BORREGAARD, N;HERLIN, T
通讯作者：
HERLIN, T