Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy.
Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy.
复制标题
恶性高血压的眼底病变。
DOI：
10.1016/s0161-6420(86)33554-1
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发表时间：
1986
期刊：
影响因子：
13.7
通讯作者：
Virdi,PS
中科院分区：
文献类型：
--
作者：
Hayreh,SS;Servais,GE;Virdi,PS
通过改良的戈德布拉特手术，在 60 只恒河猴中产生了实验性肾血管性恶性动脉高血压，并详细研究了高血压眼底变化（通过对所有猴子进行长期随访的连续检眼镜检查和荧光素眼底血管造影，并对 29 只眼睛进行病理学检查）。在高血压脉络膜病变中，视网膜色素上皮（RPE）病变和浆液性视网膜脱离（RD）是典型的检眼镜病变，而荧光素眼底血管造影和组织病理学研究显示，除了RPE的变化外，脉络膜血管床也有明显异常。 RPE病变可细分为（1）最初的急性局灶性病变（由于局灶性RPE梗塞）和（2）退行性病变，其发展较晚，本质上是进行性的，最大程度地累及黄斑和眼底周围区域。 RD 最常见于后极部，很少累及周边视网膜。脉络膜血管床显示循环受损以及广泛的闭塞和缺血性变化。这些研究表明，高血压脉络膜病变与高血压视网膜病变一样重要。详细讨论了高血压脉络膜病变的发病机制；有证据表明，这是由于脉络膜缺血所致，而高血压脉络膜病变和视网膜病变是肾血管性恶性高血压的两种独立且互不相关的表现。
Experimental renovascular malignant arterial hypertension was produced, by modified Goldblatt's procedures, in 60 rhesus monkeys, and hypertensive fundus changes were studied in detail (by serial ophthalmoscopy and fluorescein fundus angiography in all monkeys on a long-term follow-up, and pathologically in 29 eyes). In hypertensive choroidopathy, retinal pigment epithelial (RPE) lesions and serous retinal detachment (RD) were the classic ophthalmoscopic lesions, whereas fluorescein fundus angiography and histopathologic studies revealed marked abnormalities in the choroidal vascular bed, in addition to the changes in the RPE. The RPE lesions could be subdivided into (1) initial acute focal lesions (due to focal RPE infarction), and (2) degenerative lesions, which developed later and were progressive in nature, maximally involving the macular and peripheral regions of the fundus. The RD developed most commonly in the posterior pole and infrequently involved the peripheral retina. The choroidal vascular bed showed impaired circulation and extensive occlusive and ischemic changes. These studies revealed that hypertensive choroidopathy is as important a fundus change as hypertensive retinopathy. The pathogenesis of hypertensive choroidopathy is discussed in detail; the evidence indicates that it is due to choroidal ischemia, and that hypertensive choroidopathy and retinopathy are two independent and unrelated manifestations of renovascular malignant hypertension.
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与先兆子痫相关的双侧视网膜脱离
DOI：
10.1111/j.1479-828x.1981.tb00142.x
发表时间：
1981
影响因子：
1.7
作者：
M. McEvoy;J. Runciman;D. Edmonds;J. Kerin
通讯作者：
J. Kerin
影响因子：
4.2
作者：
FASTENBERG, DM;FETKENHOUR, CL;SHOCH, DE
通讯作者：
SHOCH, DE
影响因子：
13.7
作者：
Hayreh,SS;Servais,GE;Virdi,PS
通讯作者：
Virdi,PS
影响因子：
4.1
作者：
Sohan Singh;Jilliane A. B. Baines
通讯作者：
Jilliane A. B. Baines
脉络膜缺血性梗塞（Elschinig 斑）。
影响因子：
4.2
作者：
B. Klien;B. Klien
通讯作者：
B. Klien