The Role of Probiotics, Prebiotics and Synbiotics in Combating Multidrug-Resistant Organisms.
The Role of Probiotics, Prebiotics and Synbiotics in Combating Multidrug-Resistant Organisms.
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DOI：
10.1016/j.clinthera.2020.06.011
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发表时间：
2020-09
影响因子：
3.2
通讯作者：
Arshad M
中科院分区：
文献类型：
--
作者：
Newman AM;Arshad M
耐多药微生物的流行在全球范围内不断增加，对全球卫生保健系统构成了独特的挑战。需要新的方法来对抗这些生物体感染的传播。肠道微生物组，特别是耐药基因组，在预防这些生物体感染以及在社区内获得和传播方面提供了独特的靶标。我们强调了一种对抗多重耐药生物体的新方法：使用益生元，益生菌和合生元来操纵微生物组和耐药组。本文综述了迄今为止与这些产品相关的已发表文献和临床试验，重点是有效的试验。它强调了每种产品的可能作用机制，以及其在选择性人群中的安全性。最终，尽管在对这3种干预措施中的任何一种的有效性做出明确声明之前还需要进一步的研究，但迄今为止的文献为对抗细菌耐药性提供了新的希望和新的工具。
The prevalence of multidrug-resistant organisms is increasing worldwide, posing a unique challenge to global health care systems. Novel approaches are needed to combat the spread of infection with these organisms. The enteric microbiome, and in particular the resistome, offers a unique target in both the prevention of infection with these organisms and the acquisition and spread within the community. We highlight a novel approach to combat multidrug-resistant organisms: the use of prebiotics, probiotics, and synbiotics to manipulate the microbiome and resistome. This review summarizes the published literature and clinical trials related to these products to date, with a focus on efficacious trials. It highlights the probable mechanism of action for each product, as well as its safety profile in selective populations. Ultimately, although further research is needed before a definitive statement can be made on the efficacy of any of these 3 interventions, the literature to date offers new hope and a new tool in the arsenal in the fight against bacterial drug resistance.
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