Ocular and extraocular roles of neuropsin in vertebrates.
Ocular and extraocular roles of neuropsin in vertebrates.
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DOI：
10.1016/j.tins.2021.11.008
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发表时间：
2022-03
影响因子：
15.9
通讯作者：
Panda S
中科院分区：
文献类型：
--
作者：
Calligaro H;Dkhissi-Benyahya O;Panda S
探测和适应不同水平的环境光的能力对动物的生存至关重要。光检测是视觉的基础，但光也调节眼睛的发育，并驱动几种非成像功能，包括使昼夜节律与日常的明/暗周期同步，限制瞳孔对光强度的变化，以及调节对光的反应情绪。直到21世纪初，这些功能还被认为完全由眼睛光感受器介导。然而，随着新的方法揭示了以前未被认识到的神经抑制素的功能，一种对紫外线敏感的视蛋白--神经抑素(OPN5)受到了越来越多的关注。事实上，最近首次在哺乳动物中描述了OPN5介导的眼外和脑深部光接收。本文就OPN5在脊椎动物中的特性和功能的研究现状进行综述。
The ability to detect and adapt to different levels of ambient light is critical for animal survival. Light detection is the basis of vision, but light also regulates eye development and drives several non-image-forming functions, including synchronizing circadian rhythms to the daily light/dark cycle, restricting pupils in response to changes in light intensity, and modulating mood in response to light. Until the early 2000s, these functions were thought to be solely mediated by ocular photoreceptors. However, neuropsin (OPN5), a UV-sensitive opsin, has been receiving growing attention, as new methods have revealed previously unappreciated functions of neuropsin. In fact, OPN5-mediated extraocular and deep-brain photoreception have recently been described for the first time in mammals. This review aims to synthesize current knowledge of the properties and functions of OPN5 across vertebrates.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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