Maternal smoking and the risk of still birth: systematic review and meta-analysis.
Maternal smoking and the risk of still birth: systematic review and meta-analysis.
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DOI：
10.1186/s12889-015-1552-5
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发表时间：
2015-03-13
影响因子：
4.5
通讯作者：
Lewis S
中科院分区：
文献类型：
--
作者：
Marufu TC;Ahankari A;Coleman T;Lewis S
众所周知，怀孕期间吸烟与一系列不良妊娠结局有关，但在许多国家，孕妇吸烟的流行率很高，这仍然是一个主要的公共卫生问题。我们进行了一项系统的综述和荟萃分析，以提供怀孕期间母亲吸烟与死产风险之间的联系的当代估计。我们检索了MEDLINE、EMBASE、Artich Info和Web of Science四个数据库，检索了截至2012年12月31日的所有相关原始研究。我们包括了一些观察性研究，这些研究测量了孕妇在怀孕期间吸烟与死产风险之间的关系。共筛选出1766篇文献进行标题分析，其中34篇文献(21篇队列，8篇病例对照，5篇横断面研究)符合纳入标准。Meta分析显示，孕期吸烟与死产风险增加47%显著相关(OR1.47，95%CI1.37，1.57，p <； 0.0001)。在亚组分析中，每天吸烟1-9支和≥每天10支与死产几率分别增加9%和52%相关。随后，定义 ≥ 20周死胎的研究表明，与不吸烟的母亲相比，吸烟母亲的死胎几率增加43%(OR1.43，95%可信区间1.32，1.54，p <； 0.0001)，而定义 ≥ 24周和 ≥ 28周死胎的研究显示，死产几率分别增加58%和33%。我们的综述证实了怀孕期间母亲吸烟对死产风险的剂量反应效应。为了将死产的风险降到最低，降低目前怀孕期间的吸烟流行率应该继续是关键的公共卫生高度优先事项。本文的在线版本(doi：10.1186/s12889-0151552-5)包含补充材料，授权用户可以使用。
Smoking in pregnancy is known to be associated with a range of adverse pregnancy outcomes, yet there is a high prevalence of smoking among pregnant women in many countries, and it remains a major public health concern. We have conducted a systematic review and meta-analysis to provide contemporary estimates of the association between maternal smoking in pregnancy and the risk of stillbirth. We searched four databases namely MEDLINE, EMBASE, Psych Info and Web of Science for all relevant original studies published until 31st December 2012. We included observational studies that measured the association between maternal smoking during pregnancy and the risk of stillbirth. 1766 studies were screened for title analysis, of which 34 papers (21 cohorts, 8 case controls and 5 cross sectional studies) met the inclusion criteria. In meta-analysis smoking during pregnancy was significantly associated with a 47% increase in the odds of stillbirth (OR 1.47, 95% CI 1.37, 1.57, p < 0.0001). In subgroup analysis, smoking 1-9 cig/day and ≥10 cig/day was associated with an 9% and 52% increase in the odds of stillbirth respectively. Subsequently, studies defining stillbirth at ≥ 20 weeks demonstrated a 43% increase in odds for smoking mothers compared to mothers who do not smoke, (OR 1.43, 95% CI 1.32, 1.54, p < 0.0001), whereas studies with stillbirth defined at ≥ 24 weeks and ≥ 28 weeks showed 58% and 33% increase in the odds of stillbirth respectively. Our review confirms a dose-response effect of maternal smoking in pregnancy on risk of stillbirth. To minimise the risk of stillbirth, reducing current smoking prevalence in pregnancy should continue to be a key public health high priority. The online version of this article (doi:10.1186/s12889-015-1552-5) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/0020-7292(91)90532-a
发表时间：
1991-01-01
影响因子：
3.8
作者：
FERRAZ, EM;GRAY, RH
通讯作者：
GRAY, RH
影响因子：
120.7
作者：
Bukowski, Radek;Carpenter, Marshall;Willinger, Marian
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Willinger, Marian
影响因子：
1.8
作者：
Aliyu, Muktar H.;Salihu, Hamisu M.;Clayton, Heather B.
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Clayton, Heather B.
DOI：
10.1136/fn.87.2.f118
发表时间：
2002-09-01
影响因子：
4.4
作者：
Froen, JF;Arnestad, M;Stray-Pedersen, B
通讯作者：
Stray-Pedersen, B
DOI：
10.1111/j.1471-0528.2007.01340.x
发表时间：
2007-06
期刊：
BJOG : an international journal of obstetrics and gynaecology
影响因子：
--
作者：
Högberg L;Cnattingius S
通讯作者：
Cnattingius S