Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases.

Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases.
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DOI:
10.3389/fphys.2020.596507
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发表时间:
2020
影响因子:
4
通讯作者:
Wong BJ
Wong BJ
中科院分区:
医学2区
文献类型:
--
作者:
Turner CG;Stanhewicz AE;Wong BJ

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许多关于血管功能的研究将绝经前女性参与者的测试限制在女性性激素(无论是内源性还是外源性)浓度最低的时期。这种做法,当不是特定研究问题的一部分时,可能会限制有关绝经前女性主要生理状态的数据,并对外部有效性构成威胁。在这方面,我们简要回顾了关于女性性激素对血管功能影响的文献,并讨论了何时将实验测试限制在月经周期(MC)的某个阶段或口服避孕药(OC)可能是合适的。本透视的目的是打开一个对话,可以提高数据的有效性和对绝经前女性血管功能的整体理解。
Many studies of vascular function limit the testing of premenopausal female participants to periods when female sex hormones, either endogenous or exogenous, are at their lowest concentration. This practice, when not part of the specific research question, may limit data surrounding the predominant physiological state of premenopausal females and pose a threat to external validity. In this Perspective, we briefly review the literature on the effect of female sex hormones on vascular function and discuss when limiting experimental testing to a certain phase of the menstrual cycle (MC) or oral contraceptive (OC) use may be appropriate. The goal of this Perspective is to open a dialog that may enhance data validity and the overall understanding of vascular function in premenopausal females.
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