Bypassing Different Parts of the Small Intestine Determines Different Metabolic Effects in Streptozotocin-Induced Diabetic Rats
Bypassing Different Parts of the Small Intestine Determines Different Metabolic Effects in Streptozotocin-Induced Diabetic Rats
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绕过小肠的不同部分决定了链脲佐菌素诱导的糖尿病大鼠的不同代谢效应
DOI：
10.1007/s11695-021-05785-0
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发表时间：
2022-01
期刊：
影响因子：
2.9
通讯作者：
段金元
中科院分区：
文献类型：
--
作者：
谭彩;陶芳;郑智华;罗欣;庞强;曹家庆;段金元
伴有近端袢结扎的空肠回肠侧侧分流术（SSJIBL）具有显著的降糖和体重控制效果；然而，没有研究阐明在SSJIBL中哪个肠段最有效。本研究调查了近端……的效果（原文此处“proximal sm”不完整）
PurposeSide-to-side jejunoileal bypass with proximal loop ligation (SSJIBL) has significant glucose-lowering and weight-control effects; however, no study has elucidated which segment is most effective in SSJIBL. This study investigated the effect of proximal small intestinal bypass (PSIB), middle small intestinal bypass (MSIB), and distal small intestinal bypass (DSIB) on metabolic improvement in streptozotocin (STZ)-induced diabetic rats.Materials and MethodsSTZ-induced diabetic rats were divided into four groups: PSIB, MSIB, DSIB, and sham-operated. The primary outcome measures were body weight, food intake, fasting blood glucose (FBG) levels, oral glucose tolerance (OGTT), insulin tolerance (ITT), serum insulin, gut hormones, serum lipid profile, and liver function levels.ResultsGlobal body weight in the DSIB group was lower than that in the PSIB group. The global food intake in the PSIB group was lower than that in the MSIB group. The PSIB group had a slightly better glucose-lowering effect than the MSIB and DSIB groups. The PSIB, MSIB, and DSIB groups all had improvement in insulin sensitivity at postoperative week 6. The MSIB group exhibited the best improvement in lipid homeostasis. Serum insulin and leptin levels were higher, and serum ghrelin levels were lower in the operated groups than in the sham group.ConclusionsThis study provides experimental evidence that PSIB surgery induces a better glucose-lowering effect than DSIB surgery, and MSIB induced the best improvement in lipid homeostasis, whereas DSIB was even more advantageous in terms of weight control in the STZ-induced diabetic rat model.Graphical abstract
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DOI：
10.1016/j.ecl.2006.06.002
发表时间：
2006-09-01
影响因子：
4.5
作者：
Chahil, Tina J.;Ginsberg, Henry N.
通讯作者：
Ginsberg, Henry N.
影响因子：
2.9
作者：
Jinyuan Duan;Lianwen Yuan;Jianping Zhou
通讯作者：
Jinyuan Duan;Lianwen Yuan;Jianping Zhou
影响因子：
9
作者：
GRIFFEN, WO;YOUNG, VL;STEVENSON, CC
通讯作者：
STEVENSON, CC
影响因子：
2.9
作者：
A. Hassn;A. Luhmann;S. Rahmani;G. Morris-Stiff
通讯作者：
A. Hassn;A. Luhmann;S. Rahmani;G. Morris-Stiff
影响因子：
7.1
作者：
He, Siran;Ngoc-Anh Le;Stein, Aryeh D.
通讯作者：
Stein, Aryeh D.