Estimation of the relative sensitivity of the comparative tuberculin skin test in tuberculous cattle herds subjected to depopulation.
Estimation of the relative sensitivity of the comparative tuberculin skin test in tuberculous cattle herds subjected to depopulation.
复制标题
DOI：
10.1371/journal.pone.0043217
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
McKinley TJ
中科院分区：
文献类型：
--
作者：
Karolemeas K;de la Rua-Domenech R;Cooper R;Goodchild AV;Clifton-Hadley RS;Conlan AJ;Mitchell AP;Hewinson RG;Donnelly CA;Wood JL;McKinley TJ
Bovine tuberculosis (bTB) is one of the most serious economic animal health problems affecting the cattle industry in Great Britain (GB), with incidence in cattle herds increasing since the mid-1980s. The single intradermal comparative cervical tuberculin (SICCT) test is the primary screening test in the bTB surveillance and control programme in GB and Ireland. The sensitivity (ability to detect infected cattle) of this test is central to the efficacy of the current testing regime, but most previous studies that have estimated test sensitivity (relative to the number of slaughtered cattle with visible lesions [VL] and/or positive culture results) lacked post-mortem data for SICCT test-negative cattle. The slaughter of entire herds (“whole herd slaughters” or “depopulations”) that are infected by bTB are occasionally conducted in GB as a last-resort control measure to resolve intractable bTB herd breakdowns. These provide additional post-mortem data for SICCT test-negative cattle, allowing a rare opportunity to calculate the animal-level sensitivity of the test relative to the total number of SICCT test-positive and negative VL animals identified post-mortem (rSe). In this study, data were analysed from 16 whole herd slaughters (748 SICCT test-positive and 1031 SICCT test-negative cattle) conducted in GB between 1988 and 2010, using a Bayesian hierarchical model. The overall rSe estimate of the SICCT test at the severe interpretation was 85% (95% credible interval [CI]: 78–91%), and at standard interpretation was 81% (95% CI: 70–89%). These estimates are more robust than those previously reported in GB due to inclusion of post-mortem data from SICCT test-negative cattle.
登录
查看更多内容
影响因子：
3.3
作者：
MONAGHAN, ML;DOHERTY, ML;QUINN, PJ
通讯作者：
QUINN, PJ
影响因子：
4.4
作者：
Coad, Michael;Clifford, Derek;Whelan, Adam O.
通讯作者：
Whelan, Adam O.
影响因子：
2.4
作者：
DOHERTY, ML;MONAGHAN, ML;QUINN, PJ
通讯作者：
QUINN, PJ
影响因子：
1.4
作者：
de Jong, H;Ekdahl, M O
通讯作者：
Ekdahl, M O
影响因子：
2.6
作者：
Karolemeas, K.;McKinley, T. J.;Wood, J. L. N.
通讯作者：
Wood, J. L. N.