Trans-regulation of RNA-binding protein motifs by microRNA.
Trans-regulation of RNA-binding protein motifs by microRNA.
复制标题
MicroRNA对RNA结合蛋白基序的反式调节。
DOI：
10.3389/fgene.2014.00079
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发表时间：
2014
影响因子：
3.7
通讯作者：
Tenenbaum SA
中科院分区：
文献类型：
--
作者：
Doyle F;Tenenbaum SA
The wide array of vital functions that RNA performs is dependent on its ability to dynamically fold into different structures in response to intracellular and extracellular changes. RNA-binding proteins regulate much of this activity by targeting specific RNA structures or motifs. One of these structures, the 3-way RNA junction, is characteristically found in ribosomal RNA and results from the RNA folding in cis, to produce three separate helices that meet around a central unpaired region. Here we demonstrate that 3-way junctions can also form in trans as a result of the binding of microRNAs in an unconventional manner with mRNA by splinting two non-contiguous regions together. This may be used to reinforce the base of a stem-loop motif being targeted by an RNA-binding protein. Trans interactions between non-coding RNA and mRNA may be used to control the post-transcriptional regulatory code and suggests a possible role for some of the recently described transcripts of unknown function expressed from the human genome.
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影响因子：
64.5
作者：
Hafner M;Landthaler M;Burger L;Khorshid M;Hausser J;Berninger P;Rothballer A;Ascano M Jr;Jungkamp AC;Munschauer M;Ulrich A;Wardle GS;Dewell S;Zavolan M;Tuschl T
通讯作者：
Tuschl T
影响因子：
14.9
作者：
Grillo G;Turi A;Licciulli F;Mignone F;Liuni S;Banfi S;Gennarino VA;Horner DS;Pavesi G;Picardi E;Pesole G
通讯作者：
Pesole G
影响因子：
14.9
作者：
Grillo, G;Licciulli, F;Pesole, G
通讯作者：
Pesole, G
影响因子：
3.7
作者：
Kapranov P;St Laurent G
通讯作者：
St Laurent G
影响因子：
3.8
作者：
Calaluce R;Gubin MM;Davis JW;Magee JD;Chen J;Kuwano Y;Gorospe M;Atasoy U
通讯作者：
Atasoy U