Impact of continuous positive airway pressure treatment on left atrial volume and function in patients with obstructive sleep apnoea assessed by real-time three-dimensional echocardiography.
Impact of continuous positive airway pressure treatment on left atrial volume and function in patients with obstructive sleep apnoea assessed by real-time three-dimensional echocardiography.
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DOI：
10.1136/hrt.2009.173625
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Poyares D
中科院分区：
文献类型：
--
作者：
Oliveira W;Campos O;Cintra F;Matos L;Vieira ML;Rollim B;Fujita L;Tufik S;Poyares D
据报道，阻塞性睡眠呼吸暂停（OSA）是左心室（LV）舒张功能障碍和左心房（LA）重塑的预测因子。本研究的目的是评估使用持续气道正压通气装置 (CPAP) 治疗 OSA 对左心室容量和功能以及左心室舒张功能的影响。总共有 56 名 OSA 患者接受了研究。所有患者均接受实时三维（RT3DE）和二维超声心动图以及组织多普勒评估，以估计左心室体积、功能和左心室舒张性能。随机选择 30 例呼吸暂停低通气指数大于 20 的患者接受假 CPAP（n = 15）或有效 CPAP（n = 15）治疗 24 周。他们在三个不同的场合接受了回声检查：基线时、CPAP 12 周和 24 周或假 CPAP 后。在有效 CPAP 组中，我们观察到从基线到 24 周回声评估的以下变化：(a) E/E' 比值降低（10.3 (1.9) 至 7.9 (1.3)，p = 0.03）； (b) LA 被动排空分数增加（28.8% (11.9%) 至 46.8% (9.3%)，p = 0.01）； (c) LA 主动排空分数降低（42.7% (11.5%) 至 25.7 (15.7)，p<0.01）。在假手术组中，从基线到 24 周回声没有变化。我们发现24周/基线LA主动排空量与24周/基线E/E'比率之间呈正相关（r = 0.40，p<0.05），24周/基线LA被动排空量与24周/基线E/E'比率之间呈负相关（r = −0.53，p<0.05）。 LA 总排空分数未发现显着变化。 CPAP 改善了 OSA 患者的左心室舒张功能和左心室被动排空，但没有改善左心室结构变量。 NCT00768807。
Obstructive sleep apnoea (OSA) has been reported as a predictor of left ventricle (LV) diastolic dysfunction and left atrium (LA) remodelling. The aim of this study is to evaluate the impact of OSA treatment with a continuous positive airway pressure device (CPAP) on the LA volume and function, as well as on the LV diastolic function. In total, 56 OSA patients were studied. All patients underwent real-time three-dimensional (RT3DE) and two-dimensional echocardiogram with tissue Doppler evaluation in order to estimate LA volumes, function and LV diastolic performance. A total of 30 patients with an apnoea-hypopnoea index greater than 20 were randomly selected to receive sham CPAP (n = 15) or effective CPAP (n = 15) for 24 weeks. They underwent echo examination on three different occasions: at baseline, after 12 weeks and 24 weeks of CPAP or sham CPAP. In the effective CPAP group we observed the following changes from the baseline to the 24-week echo evaluation: (a) a reduction in the E/E′ ratio (10.3 (1.9) to 7.9 (1.3), p = 0.03); (b) an increase in the LA passive emptying fraction (28.8% (11.9%) to 46.8% (9.3%), p = 0.01); and (c) a reduction in the LA active emptying fraction (42.7% (11.5%) to 25.7 (15.7), p<0.01). In the sham group, there were no changes from the baseline to the 24-week echo. We found a positive correlation between 24 week/baseline LA active emptying volume and 24 week/baseline E/E′ ratios (r = 0.40, p<0.05) and a negative correlation between 24 week/baseline LA passive emptying volume and 24 week/baseline E/E′ ratios (r = −0.53, p<0.05). No significant changes were found on LA total emptying fraction. CPAP improved LV diastolic function and LA passive emptying, but not LA structural variables in OSA patients. NCT00768807.
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影响因子：
15.9
作者：
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通讯作者：
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影响因子：
158.5
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作者：
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DOI：
10.1016/j.echo.2006.11.017
发表时间：
2007-06-01
影响因子：
6.5
作者：
Anwar, Ashraf M.;Soliman, Osama I. I.;ten Cate, Folkert J.
通讯作者：
ten Cate, Folkert J.