Progress in the Development of Universal Influenza Vaccines.
Progress in the Development of Universal Influenza Vaccines.
复制标题
DOI：
10.3390/v12091033
复制
发表时间：
2020-09-17
期刊：
影响因子：
--
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Sun W;Luo T;Liu W;Li J
流感病毒对人类健康构成重大威胁。它们每年造成大量死亡，并对全球经济产生严重影响。流感病毒亚型众多，抗原变异不断发生，流行趋势难以预测--这些都导致针对目标毒株亚型的常规疫苗接种效果不佳。因此，开发通用流感疫苗仍然是控制流感的理想策略。本文综述了利用新技术和新策略开发针对流感病毒血凝素（HA）、神经氨酸酶（NA）等结构蛋白保守区的通用疫苗的研究进展，旨在加深对通用流感疫苗的认识，为开发流感病毒天然免疫提供参考。
Influenza viruses pose a significant threat to human health. They are responsible for a large number of deaths annually and have a serious impact on the global economy. There are numerous influenza virus subtypes, antigenic variations occur continuously, and epidemic trends are difficult to predict—all of which lead to poor outcomes of routine vaccination against targeted strain subtypes. Therefore, the development of universal influenza vaccines still constitutes the ideal strategy for controlling influenza. This article reviews the progress in development of universal vaccines directed against the conserved regions of hemagglutinin (HA), neuraminidase (NA), and other structural proteins of influenza viruses using new technologies and strategies with the goals of enhancing our understanding of universal influenza vaccines and providing a reference for research into the exploitation of natural immunity against influenza viruses.
登录
查看更多内容
影响因子：
3.7
作者：
Florek KR;Kamlangdee A;Mutschler JP;Kingstad-Bakke B;Schultz-Darken N;Broman KW;Osorio JE;Friedrich TC
通讯作者：
Friedrich TC
影响因子：
7.3
作者：
Awate S;Babiuk LA;Mutwiri G
通讯作者：
Mutwiri G
影响因子：
4.4
作者：
Adler-Moore, J. P.;Ernst, W.;Fujii, G.
通讯作者：
Fujii, G.
影响因子：
7.8
作者：
Corder, Brigette N.;Bullard, Brianna L.;Weaver, Eric A.
通讯作者：
Weaver, Eric A.
影响因子：
12.4
作者：
Antrobus, Richard D.;Berthoud, Tamara K.;Gilbert, Sarah C.
通讯作者：
Gilbert, Sarah C.