Case Report: Variety of Target Antigens During 1 Year Follow-Up of a Patient Initially Diagnosed With Bullous Pemphigoid.
Case Report: Variety of Target Antigens During 1 Year Follow-Up of a Patient Initially Diagnosed With Bullous Pemphigoid.
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DOI：
10.3389/fimmu.2021.825226
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发表时间：
2021
影响因子：
7.3
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Qian H;Zhou Z;Shi L;Li H;Liu W;Ai Y;Gao Y;Feng S;Hashimoto T;Li X
自身免疫性大疱性疾病（aibd），表现为皮肤和/或粘膜大疱性病变，分为天疱疮和类天疱疮疾病。对复杂AIBD病例的长期观察很少有报道。在本研究中，我们收集了1例AIBD患者在包括复发在内的病程中的7个不同时间点的血清样本，并采用我们传统的和新开发的检测自身抗体的方法进行检测。有趣的是，我们发现在整个病程中，各种自身抗体的存在和滴度都随着临床特征的变化而变化，这表明患者开始时为大疱性类天疱疮，复发时为大疱性类天疱疮和粘膜显性型寻常型天疱疮合并。
Autoimmune bullous diseases (AIBDs), presenting cutaneous and/or mucosal bullous lesions, are classified into pemphigus and pemphigoid diseases. A longtime observation for complicated AIBD cases is rarely reported. In this study, serum samples of one AIBD patient were collected at seven different time points during the disease course including a relapse, which were examined by our conventional and newly developed methods for the detection of autoantibodies. Interestingly, we found changes of both the presence and the titers of various autoantibodies in accordance with the changes of clinical features during the whole disease course, which indicated that the patient started as bullous pemphigoid and relapsed as concurrence of bullous pemphigoid and mucosal-dominant-type pemphigus vulgaris.
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影响因子：
3.7
作者：
Chiorean R;Danescu S;Virtic O;Mustafa MB;Baican A;Lischka A;Hashimoto T;Kariya Y;Koch M;Sitaru C
通讯作者：
Sitaru C
影响因子：
7.3
作者：
Qian H;Natsuaki Y;Koga H;Kawakami T;Tateishi C;Tsuruta D;Ishii N;Li X;Hashimoto T
通讯作者：
Hashimoto T
影响因子：
1.7
作者：
Muhammed N;Korgaonkar S;Pradhan V;Khopkar US
通讯作者：
Khopkar US
影响因子：
4.1
作者：
Takahashi, H;Anzai, H;Nishikawa, T
通讯作者：
Nishikawa, T
影响因子：
3.6
作者：
Feng, Suying;Wu, Qinxue;Shao, Changgeng
通讯作者：
Shao, Changgeng