Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies.
Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies.
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DOI：
10.1016/j.addr.2021.113999
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发表时间：
2021-12
影响因子：
16.1
通讯作者：
Green JJ
中科院分区：
文献类型：
--
作者：
Karlsson J;Luly KM;Tzeng SY;Green JJ
Glioblastoma (GBM) is an aggressive central nervous system cancer with a dismal prognosis. The standard of care involves surgical resection followed by radiotherapy and chemotherapy, but five-year survival is only 5.6% despite these measures. Novel therapeutic approaches, such as immunotherapies, targeted therapies, and gene therapies, have been explored to attempt to extend survival for patients. Nanoparticles have been receiving increasing attention as promising vehicles for non-viral nucleic acid delivery in the context of GBM, though delivery is often limited by low blood-brain barrier permeability, particle instability, and low trafficking to target brain structures and cells. In this review, nanoparticle design considerations and new advances to overcome nucleic acid delivery challenges to treat brain cancer are summarized and discussed.
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影响因子：
16.6
作者：
Anraku Y;Kuwahara H;Fukusato Y;Mizoguchi A;Ishii T;Nitta K;Matsumoto Y;Toh K;Miyata K;Uchida S;Nishina K;Osada K;Itaka K;Nishiyama N;Mizusawa H;Yamasoba T;Yokota T;Kataoka K
通讯作者：
Kataoka K
DOI：
10.1038/mtna.2013.30
发表时间：
2013-06-18
期刊：
Molecular therapy. Nucleic acids
影响因子：
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作者：
通讯作者：
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DOI：
10.1073/pnas.97.23.12846
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2000-11-07
影响因子：
11.1
作者：
Aboody, KS;Brown, A;Snyder, EY
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影响因子：
8.8
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Abels, Erik R.;Maas, Sybren L. N.;Breakefield, Xandra O.
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Breakefield, Xandra O.
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影响因子：
8.3
作者：
Abedi-Gaballu F;Dehghan G;Ghaffari M;Yekta R;Abbaspour-Ravasjani S;Baradaran B;Dolatabadi JEN;Hamblin MR
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